Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

• Published in: Cell reports (Cambridge) Vol. 40; no. 3; p. 111112
• Main Authors: Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J., Guglielmetti, Simone, Greiff, Victor, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 19.07.2022; Cell Press
• Subjects: dysbiosis; extracellular ATP; microbiota; purinergic signaling; secretory IgA; T follicular helper cell; microbiota; CP: Immunology; purinergic signaling; secretory IgA; T follicular helper cell; dysbiosis; extracellular ATP

Secretory immunoglobulin A (SIgA) interaction with commensal bacteria conditions microbiota composition and function. However, mechanisms regulating reciprocal control of microbiota and SIgA are not defined. Bacteria-derived adenosine triphosphate (ATP) limits T follicular helper (Tfh) cells in the...