Aneuploidies, deletion, and overexpression of TP53 gene in intestinal metaplasia of patients without gastric cancer

• Published in: Cancer genetics and cytogenetics Vol. 153; no. 2; pp. 127 - 132
• Main Authors: César, Ana Cristina Gobbo, Borim, Aldenis Albaneze, Caetano, Alaor, Cury, Patrícia Maluf, Silva, Ana Elizabete
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2004
• Subjects: Adult; Aged; Aged, 80 and over; Aneuploidy; Chromosome Aberrations; Gene Deletion; Genes, p53 - genetics; Humans; Intestinal Diseases - genetics; Intestinal Diseases - pathology; Intestinal Neoplasms - genetics; Intestinal Neoplasms - pathology; Metaplasia - genetics; Metaplasia - pathology; Middle Aged; Neoplasm Staging

Gastric carcinogenesis is attributable to interacting environmental and genetic factors, through a sequence of events including intestinal metaplasia. Using a fluorescence in situ hybridization technique, we investigated the occurrence of aneuploidies of chromosomes 3, 7, 8, 9, and 17, TP53 gene del...