Dual‐Crosslinked Amorphous Polysaccharide Hydrogels Based on Chitosan/Alginate for Wound Healing Applications

• Published in: Macromolecular rapid communications. Vol. 39; no. 20; pp. e1800069 - n/a
• Main Authors: Hu, Yang, Zhang, Zhenyan, Li, Yang, Ding, Xiaokang, Li, Dawei, Shen, Chuanan, Xu, Fu‐Jian
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2018
• Subjects: ALG; Alginates; Alginates - administration & dosage; Alginates - chemistry; Alginic acid; Animals; Bandages; Cell growth; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Cellular Microenvironment - drug effects; Chelation; Chitosan; Chitosan - administration & dosage; Chitosan - analogs & derivatives; Chitosan - chemistry; Cicatrix - microbiology; Cicatrix - prevention & control; CMC; Cross-Linking Reagents - administration & dosage; Cross-Linking Reagents - chemistry; Crosslinking; EGF; Electrostatic properties; Epidermal growth factor; Epidermal Growth Factor - genetics; Growth factors; Humans; Hydrogels; Hydrogels - administration & dosage; Hydrogels - chemistry; Inflammation - microbiology; Inflammation - prevention & control; Mice; Polysaccharides; Polysaccharides - chemistry; Rheological properties; Rheology; Scars; Wound healing; Wound Healing - drug effects; CMC; wound healing; hydrogels; ALG; EGF

Development of advanced wound dressing materials with rapid healing rates is in urgent demand for wound cares. A suitable microenvironment will promote cell proliferation and migration, which benefits to early wound healing and prevents inflammations and scars. In this work, N‐carboxymethyl chitosan...