Effect of highly radiolabelled 2,4-dinitrochlorobenzene (DNCB) on experimental DNCB contact dermatitis in guinea pigs

• Published in: Allergy (Copenhagen) Vol. 39; no. 7; p. 499
• Main Authors: Filipp, G, Biro, G, Bahmer, F, Mitschke, H, Lehmann, G
• Format: Journal Article
• Language: English
• Published: Denmark 01.10.1984
• Subjects: Animals; Dermatitis, Contact - etiology; Dermatitis, Contact - pathology; Dinitrochlorobenzene - toxicity; Epitopes; Guinea Pigs; Immune Tolerance - radiation effects; Iodine Radioisotopes; Nitrobenzenes - toxicity; T-Lymphocytes - radiation effects

With the aid of epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) solution in acetone, we induced a cutaneous allergic reaction of the delayed type. Our question was whether the development of the DNCB cutaneous sensitivity could be suppressed by highly radiolabelled DNCB. On the basis of...