Biodegradable Polymers as a Noncoding miRNA Nanocarrier for Multiple Targeting Therapy of Human Hepatocellular Carcinoma

• Published in: Advanced healthcare materials Vol. 8; no. 8; pp. e1801318 - n/a
• Main Authors: Yang, Chengbin, Yin, Mingjie, Xu, Gaixia, Lin, Wei‐Jen, Chen, Jiajie, Zhang, Yinling, Feng, Tao, Huang, Peng, Chen, Chih‐Kuang, Yong, Ken‐Tye
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2019
• Subjects: Apoptosis; Biodegradability; biodegradable; Cell migration; Endocytosis; Gene expression; Hepatocellular carcinoma; Liver cancer; miRNA; miRNA delivery; multiple targeting; PEGylation; Restoration; Strategy; Therapy; Tumor suppressor genes; miRNA delivery; biodegradable; PEGylation; multiple targeting; hepatocellular carcinoma

Therapeutic strategy based on the restoration of tumor suppressor‐microRNAs (miRNAs) is a promising approach for cancer therapy, but the low delivery efficiency of miRNA remains a huge hurdle due to the lack of safe and efficient nonviral carriers. In this work, with the use of newly developed PEGyl...