The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

• Published in: Clinical pharmacology and therapeutics Vol. 108; no. 1; pp. 40 - 53
• Main Authors: Nigam, Sanjay K., Bush, Kevin T., Bhatnagar, Vibha, Poloyac, Samuel M., Momper, Jeremiah D.
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Animals; Biological Transport; Drug Development - methods; Enzymes - metabolism; Humans; Membrane Transport Proteins - metabolism; Metabolomics; Models, Biological; Pharmaceutical Preparations - metabolism; Systems Biology - methods

Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug discovery and development. It is now time to fully rethink the biological functions of drug metabolizing enzymes (DMEs) and transporters within the framework of QSP models. The large set of DME and transporter ge...