Direct Enamido C(sp2)−H Diphosphorylation Enabled by a PCET‐Triggered Double Radical Relay: Access to gem‐Bisphosphonates

• Published in: Chemistry : a European journal Vol. 26; no. 24; pp. 5515 - 5521
• Main Authors: Cao, Hao‐Qiang, Liu, Hao‐Nan, Liu, Zhe‐Yuan, Qiao, Bao‐Kun, Zhang, Fa‐Guang, Ma, Jun‐An
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 24.04.2020; Wiley Subscription Services, Inc
• Subjects: Bisphosphonates; Chemistry; Chemistry, Multidisciplinary; enamides; Physical Sciences; radical relay; Science & Technology; silver; synthetic methods; REGIOSELECTIVE PHOSPHONATION; enamides; DRUG-DELIVERY; NITROGEN-CONTAINING BISPHOSPHONATES; H-PHOSPHONATES; ALKYNES; radical relay; BIOLOGICAL EVALUATION; DIPHOSPHATE SYNTHASE; bisphosphonates; silver; BONE; PD(II)-CATALYZED PHOSPHORYLATION; PALLADIUM-CATALYZED PHOSPHONATION; synthetic methods

Herein we report a novel and straightforward protocol for the construction of valuable gem‐BPs by means of proton‐coupled electron‐transfer (PCET)‐triggered enamido C(sp2)−H diphosphorylation. This reaction represents a rare example of realizing the challenging double C−P bond formation at a single...