Platelet‐Facilitated Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

• Published in: Angewandte Chemie International Edition Vol. 57; no. 4; pp. 986 - 991
• Main Authors: Rao, Lang, Bu, Lin‐Lin, Ma, Liang, Wang, Wenbiao, Liu, Huiqin, Wan, Da, Liu, Jian‐Feng, Li, Andrew, Guo, Shi‐Shang, Zhang, Lu, Zhang, Wen‐Feng, Zhao, Xing‐Zhong, Sun, Zhi‐Jun, Liu, Wei
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 22.01.2018
• Edition: International ed. in English
• Subjects: Animals; Blood circulation; Blood Platelets - chemistry; Blood Platelets - cytology; Cancer; cancer therapy; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Proliferation - radiation effects; drug delivery; Electroporation; Gold; Gold - chemistry; Head & neck cancer; Humans; Irradiation; Lasers; Mice; Mice, Inbred ICR; Mice, Knockout; Microscopy, Confocal; nanomedicine; Nanorods; Nanotubes - chemistry; Nanotubes - toxicity; Phototherapy; photothermal therapy; Platelets; PTEN Phosphohydrolase - deficiency; PTEN Phosphohydrolase - genetics; RAW 264.7 Cells; Receptor, Transforming Growth Factor-beta Type I - deficiency; Receptor, Transforming Growth Factor-beta Type I - genetics; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - therapy; Therapy; cancer therapy; nanomedicine; drug delivery; platelets; photothermal therapy

Here, we present a platelet‐facilitated photothermal tumor therapy (PLT‐PTT) strategy, in which PLTs act as carriers for targeted delivery of photothermal agents to tumor tissues and enhance the PTT effect. Gold nanorods (AuNRs) were first loaded into PLTs by electroporation and the resulting AuNR‐l...