Functional analysis of cytotoxic cells in patients with acute nonlymphoblastic leukemia in complete remission

• Published in: Cancer Vol. 64; no. 3; pp. 667 - 672
• Main Authors: Trentin, Livio, Pizzolo, Giovanni, Feruglio, Cristina, Zambello, Renato, Masciarelli, Maria, Bulian, Pietro, Agostini, Carlo, Vinante, Fabrizio, Zanotti, Roberta, Semenzato, Gianpietro
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.08.1989; Wiley-Liss
• Subjects: Adult; Biological and medical sciences; Cytotoxicity, Immunologic; Female; Hematologic and hematopoietic diseases; Humans; In Vitro Techniques; Interleukin-2 - pharmacology; Killer Cells, Natural - immunology; Leukemia, Myeloid, Acute - immunology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocytes, Mononuclear - immunology; Male; Medical sciences; Middle Aged; Remission Induction; Human; Acute; Cytotoxicity; Activation; Hemopathy; Monoclonal antibody; In vitro; Nonlymphocytic leukemia; Blood; Mononuclear cell; Interleukin 2; Remission; Target cell; Tumor cell

In the current study, we investigated the cytotoxic ability of peripheral blood mononuclear cells (PBMC) recovered from patients with acute nonlymphoblastic leukemia (ANLL) in complete remission (CR) against natural killer (NK)‐sensitive, NK‐resistant, autologous and allogeneic leukemic target cells...