Hepatoblastoma in Explanted Livers of Patients With Biliary Atresia

ABSTRACT Objectives: Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study ai...

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Published inJournal of pediatric gastroenterology and nutrition Vol. 63; no. 2; pp. 188 - 194
Main Authors Amir, Achiya Z., Sharma, Ajay, Cutz, Ernest, Avitzur, Yaron, Shaikh, Furqan, Kamath, Binita M., Ling, Simon C., Ghanekar, Anand, Ng, Vicky L.
Format Journal Article
LanguageEnglish
Published United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology 01.08.2016
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Abstract ABSTRACT Objectives: Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha‐fetoprotein (aFP) as a marker in the diagnosis. Methods: A retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999 and June 2014, was conducted. Patient demographics, pre‐LTx aFP levels, and histologic examination of native liver explants were reviewed. Results: One hundred two (44% men, median age 11 months) patients underwent LTx for BA. Two (2%) explants examinations were confirmatory for concomitant HB; both patients had abnormally elevated aFP. Overall, 56 (55%) patients had available pre‐LTx aFP levels. Recipients with persistently abnormal aFP levels (n = 20, 36%) were older at hepatoportoenterostomy (107 vs 68 days, P = 0.02) and younger at LTx surgery (359 vs 1713 days, P < 0.01), compared to patients with constantly normal levels (n = 24, 43%). Conclusions: In our cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses. Elevated serum aFP levels may be sensitive but not specific for HB in this context. Further research is required to identify specific mechanisms and risk factors.
AbstractList OBJECTIVESSurveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha-fetoprotein (aFP) as a marker in the diagnosis.METHODSA retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999 and June 2014, was conducted. Patient demographics, pre-LTx aFP levels, and histologic examination of native liver explants were reviewed.RESULTSOne hundred two (44% men, median age 11 months) patients underwent LTx for BA. Two (2%) explants examinations were confirmatory for concomitant HB; both patients had abnormally elevated aFP. Overall, 56 (55%) patients had available pre-LTx aFP levels. Recipients with persistently abnormal aFP levels (n = 20, 36%) were older at hepatoportoenterostomy (107 vs 68 days, P = 0.02) and younger at LTx surgery (359 vs 1713 days, P < 0.01), compared to patients with constantly normal levels (n = 24, 43%).CONCLUSIONSIn our cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses. Elevated serum aFP levels may be sensitive but not specific for HB in this context. Further research is required to identify specific mechanisms and risk factors.
ABSTRACT Objectives: Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha‐fetoprotein (aFP) as a marker in the diagnosis. Methods: A retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999 and June 2014, was conducted. Patient demographics, pre‐LTx aFP levels, and histologic examination of native liver explants were reviewed. Results: One hundred two (44% men, median age 11 months) patients underwent LTx for BA. Two (2%) explants examinations were confirmatory for concomitant HB; both patients had abnormally elevated aFP. Overall, 56 (55%) patients had available pre‐LTx aFP levels. Recipients with persistently abnormal aFP levels (n = 20, 36%) were older at hepatoportoenterostomy (107 vs 68 days, P = 0.02) and younger at LTx surgery (359 vs 1713 days, P < 0.01), compared to patients with constantly normal levels (n = 24, 43%). Conclusions: In our cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses. Elevated serum aFP levels may be sensitive but not specific for HB in this context. Further research is required to identify specific mechanisms and risk factors.
OBJECTIVES:Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha-fetoprotein (aFP) as a marker in the diagnosis. METHODS:A retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999 and June 2014, was conducted. Patient demographics, pre-LTx aFP levels, and histologic examination of native liver explants were reviewed. RESULTS:One hundred two (44% men, median age 11 months) patients underwent LTx for BA. Two (2%) explants examinations were confirmatory for concomitant HB; both patients had abnormally elevated aFP. Overall, 56 (55%) patients had available pre-LTx aFP levels. Recipients with persistently abnormal aFP levels (n = 20, 36%) were older at hepatoportoenterostomy (107 vs 68 days, P = 0.02) and younger at LTx surgery (359 vs 1713 days, P < 0.01), compared to patients with constantly normal levels (n = 24, 43%). CONCLUSIONS:In our cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses. Elevated serum aFP levels may be sensitive but not specific for HB in this context. Further research is required to identify specific mechanisms and risk factors.
Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA). To date, only 2 published case reports describe the finding of hepatoblastoma (HB) in this setting. The present study aimed to investigate this association of HB and BA, and to assess the utility of alpha-fetoprotein (aFP) as a marker in the diagnosis. A retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999 and June 2014, was conducted. Patient demographics, pre-LTx aFP levels, and histologic examination of native liver explants were reviewed. One hundred two (44% men, median age 11 months) patients underwent LTx for BA. Two (2%) explants examinations were confirmatory for concomitant HB; both patients had abnormally elevated aFP. Overall, 56 (55%) patients had available pre-LTx aFP levels. Recipients with persistently abnormal aFP levels (n = 20, 36%) were older at hepatoportoenterostomy (107 vs 68 days, P = 0.02) and younger at LTx surgery (359 vs 1713 days, P < 0.01), compared to patients with constantly normal levels (n = 24, 43%). In our cohort, HB was found to coexist in approximately 2% of patients with BA undergoing LTx, far exceeding the hypothetical anticipated incidence of 1:10 billion for the concomitant diagnoses. Elevated serum aFP levels may be sensitive but not specific for HB in this context. Further research is required to identify specific mechanisms and risk factors.
Author Ng, Vicky L.
Ling, Simon C.
Ghanekar, Anand
Amir, Achiya Z.
Cutz, Ernest
Shaikh, Furqan
Sharma, Ajay
Avitzur, Yaron
Kamath, Binita M.
AuthorAffiliation Division of Pediatric Gastroenterology, Hepatology and Nutrition †Transplant and Regenerative Medicine Center ‡Division of Pathology, Department of Laboratory Medicine §Division of Hematology and Oncology ||Division of General Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
AuthorAffiliation_xml – name: Division of Pediatric Gastroenterology, Hepatology and Nutrition †Transplant and Regenerative Medicine Center ‡Division of Pathology, Department of Laboratory Medicine §Division of Hematology and Oncology ||Division of General Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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Cites_doi 10.1053/jhep.2003.50375
10.1038/ajg.2014.213
10.3390/ijms13011126
10.1203/00006450-198101000-00012
10.1148/radiol.2203001777
10.1055/s-2007-1007317
10.1002/pbc.24215
10.1200/JCO.2010.29.3837
10.1016/j.jpeds.2007.05.051
10.1097/MOP.0000000000000081
10.1111/his.12730
10.1002/pbc.20115
10.1053/jpsu.2003.50027
10.1200/JCO.2000.18.14.2665
10.1016/S0140-6736(09)60946-6
10.1016/S0140-6736(99)03492-3
10.1111/j.1651-2227.1976.tb04942.x
10.1002/hep.21790
10.1111/j.1399-3046.2012.01704.x
10.1002/lt.20047
10.1002/hep.510300507
10.1080/088800101750059828
10.1148/rg.266065014
10.1016/j.jpeds.2011.03.004
10.1053/jpsu.2001.21600
10.1067/mpd.2002.126001
10.1007/s00383-012-3139-x
10.1148/rg.283055108
10.1111/j.1478-3231.2011.02578.x
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References 2004; 43
1976; 65
2011; 159
2001; 220
2000; 355
2011
2009; 374
2011; 31
2014; 26
2003; 38
2012; 16
2012; 59
2012; 13
2004; 10
2015; 67
2000; 18
2014; 109
2007; 151
2002; 141
1980; 1
2008; 28
2006; 26
1994; 14
1981; 15
2012; 28
1999; 30
2001; 18
2001; 36
2011; 29
2007; 46
e_1_2_10_22_2
e_1_2_10_23_2
e_1_2_10_20_2
e_1_2_10_21_2
e_1_2_10_19_2
e_1_2_10_3_2
e_1_2_10_17_2
e_1_2_10_2_2
e_1_2_10_18_2
e_1_2_10_5_2
e_1_2_10_15_2
e_1_2_10_4_2
e_1_2_10_16_2
e_1_2_10_13_2
e_1_2_10_6_2
e_1_2_10_14_2
e_1_2_10_9_2
e_1_2_10_11_2
Howlader N (e_1_2_10_7_2) 2011
e_1_2_10_8_2
e_1_2_10_12_2
e_1_2_10_32_2
e_1_2_10_10_2
e_1_2_10_31_2
e_1_2_10_30_2
Saito S (e_1_2_10_24_2) 1980; 1
e_1_2_10_28_2
e_1_2_10_29_2
e_1_2_10_26_2
e_1_2_10_27_2
e_1_2_10_25_2
References_xml – volume: 355
  start-page: 25
  year: 2000
  end-page: 29
  article-title: The frequency and outcome of biliary atresia in the UK and Ireland
  publication-title: Lancet
– year: 2011
– volume: 26
  start-page: 362
  year: 2014
  end-page: 368
  article-title: Management of hepatoblastoma: an update
  publication-title: Curr Opin
– volume: 31
  start-page: 1485
  year: 2011
  end-page: 1493
  article-title: Biliary atresia with associated structural malformations in Canadian infants
  publication-title: Liver Int
– volume: 18
  start-page: 2665
  year: 2000
  end-page: 2675
  article-title: Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group
  publication-title: J Clin Oncol
– volume: 159
  start-page: 617
  year: 2011
  end-page: 622
  article-title: Hepatocellular carcinoma in biliary atresia: King's College Hospital experience
  publication-title: J Pediatr
– volume: 28
  start-page: 887
  year: 2012
  end-page: 891
  article-title: Can we predict the prognosis of preoperative chemotherapy
  publication-title: Pediatr Surg Int
– volume: 43
  start-page: 603
  year: 2004
  end-page: 605
  article-title: Hepatoblastoma in a girl with biliary atresia: coincidence or co‐incidence
  publication-title: Pediatr Blood Cancer
– volume: 15
  start-page: 50
  year: 1981
  end-page: 52
  article-title: Serum alpha‐fetoprotein (AFP) levels in normal infants
  publication-title: Pediatr Res
– volume: 46
  start-page: 566
  year: 2007
  end-page: 581
  article-title: Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop
  publication-title: Hepatology
– volume: 151
  start-page: 659
  year: 2007
  end-page: 665
  article-title: Biliary atresia: the Canadian experience
  publication-title: J Pediatr
– volume: 220
  start-page: 669
  year: 2001
  end-page: 676
  article-title: Conspicuity of hepatocellular nodular lesions in cirrhotic livers at ferumoxides‐enhanced MR imaging: importance of Kupffer cell number
  publication-title: Radiology
– volume: 141
  start-page: 217
  year: 2002
  end-page: 222
  article-title: A population‐based study on the incidence and possible pre‐ and perinatal etiologic risk factors of biliary atresia
  publication-title: J Pediatr
– volume: 59
  start-page: 776
  year: 2012
  end-page: 779
  article-title: The epidemiology of hepatoblastoma
  publication-title: Pediatr Blood Cancer
– volume: 13
  start-page: 1126
  year: 2012
  end-page: 1153
  article-title: Clinical significance of serum biomarkers in pediatric solid mediastinal and abdominal tumors
  publication-title: Int J Mol Sci
– volume: 26
  start-page: 1621
  year: 2006
  end-page: 1636
  article-title: MR contrast agents for liver imaging: what, when, how
  publication-title: Radiographics
– volume: 36
  start-page: 436
  year: 2001
  end-page: 439
  article-title: Liver transplantation for biliary atresia associated with malignant hepatic tumors
  publication-title: J Pediatr Surg
– volume: 28
  start-page: 747
  year: 2008
  end-page: 769
  article-title: Cirrhosis‐associated hepatocellular nodules: correlation of histopathologic and MR imaging features
  publication-title: Radiographics
– volume: 30
  start-page: 1174
  year: 1999
  end-page: 1178
  article-title: the vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification
  publication-title: Hepatology
– volume: 38
  start-page: 560
  year: 2003
  end-page: 566
  article-title: Epidemiology of primary hepatic malignancies in US children
  publication-title: Hepatology
– volume: 14
  start-page: 270
  year: 1994
  end-page: 281
  article-title: Tumors of the liver
  publication-title: Semin Liver Dis
– volume: 65
  start-page: 623
  year: 1976
  end-page: 629
  article-title: Serum alpha‐fetoprotein levels in extrahepatic biliary atresia, idiopathic neonatal hepatitis and alpha‐1‐antitrypsin deficiency (PiZ)
  publication-title: Acta Paediatr
– volume: 10
  start-page: S9
  year: 2004
  end-page: S15
  article-title: Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy‐‐a Western experience
  publication-title: Liver Transpl
– volume: 38
  start-page: 134
  year: 2003
  end-page: 137
  article-title: Hepatoblastoma in children of extremely low birth weight: a report from a single perinatal center
  publication-title: J Pediatr Surg
– volume: 18
  start-page: 11
  year: 2001
  end-page: 26
  article-title: Diagnostic value of alpha‐fetoprotein and beta‐human chorionic gonadotropin in infancy and childhood
  publication-title: J Pediatr Hematol Oncol
– volume: 1
  start-page: 99
  year: 1980
  end-page: 102
  article-title: Alpha‐fetoprotein in infantile obstructive jaundice in comparison with the normal ranges
  publication-title: Oncodev Biol Med
– volume: 109
  start-page: 1328
  year: 2014
  end-page: 1347
  article-title: ACG clinical guideline: the diagnosis and management of focal liver lesions
  publication-title: Am J Gastroenterol
– volume: 374
  start-page: 1704
  year: 2009
  end-page: 1713
  article-title: Biliary atresia
  publication-title: Lancet
– volume: 29
  start-page: 3301
  year: 2011
  end-page: 3306
  article-title: Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the children's oncology group
  publication-title: J Clin Oncol
– volume: 16
  start-page: 549
  year: 2012
  end-page: 563
  article-title: Current concepts in pediatric liver tumors
  publication-title: Pediatr Transplant
– volume: 67
  start-page: 905
  year: 2015
  end-page: 913
  article-title: Quantification of glypican 3, beta catenin and claudin‐1 protein expression in hepatoblastoma and paediatric hepatocellular carcinoma by color deconvolution
  publication-title: Histopathology
– ident: e_1_2_10_8_2
  doi: 10.1053/jhep.2003.50375
– ident: e_1_2_10_32_2
  doi: 10.1038/ajg.2014.213
– ident: e_1_2_10_18_2
  doi: 10.3390/ijms13011126
– ident: e_1_2_10_17_2
  doi: 10.1203/00006450-198101000-00012
– ident: e_1_2_10_29_2
  doi: 10.1148/radiol.2203001777
– ident: e_1_2_10_13_2
  doi: 10.1055/s-2007-1007317
– ident: e_1_2_10_22_2
  doi: 10.1002/pbc.24215
– ident: e_1_2_10_31_2
  doi: 10.1200/JCO.2010.29.3837
– ident: e_1_2_10_5_2
  doi: 10.1016/j.jpeds.2007.05.051
– ident: e_1_2_10_30_2
  doi: 10.1097/MOP.0000000000000081
– ident: e_1_2_10_19_2
  doi: 10.1111/his.12730
– ident: e_1_2_10_16_2
  doi: 10.1002/pbc.20115
– ident: e_1_2_10_21_2
  doi: 10.1053/jpsu.2003.50027
– ident: e_1_2_10_9_2
  doi: 10.1200/JCO.2000.18.14.2665
– volume: 1
  start-page: 99
  year: 1980
  ident: e_1_2_10_24_2
  article-title: Alpha‐fetoprotein in infantile obstructive jaundice in comparison with the normal ranges
  publication-title: Oncodev Biol Med
  contributor:
    fullname: Saito S
– ident: e_1_2_10_6_2
  doi: 10.1016/S0140-6736(09)60946-6
– ident: e_1_2_10_4_2
  doi: 10.1016/S0140-6736(99)03492-3
– ident: e_1_2_10_23_2
  doi: 10.1111/j.1651-2227.1976.tb04942.x
– ident: e_1_2_10_2_2
  doi: 10.1002/hep.21790
– ident: e_1_2_10_10_2
  doi: 10.1111/j.1399-3046.2012.01704.x
– ident: e_1_2_10_26_2
  doi: 10.1002/lt.20047
– ident: e_1_2_10_27_2
  doi: 10.1002/hep.510300507
– ident: e_1_2_10_11_2
  doi: 10.1080/088800101750059828
– ident: e_1_2_10_28_2
  doi: 10.1148/rg.266065014
– volume-title: SEER Cancer Statistics Review 1975‐2008
  year: 2011
  ident: e_1_2_10_7_2
  contributor:
    fullname: Howlader N
– ident: e_1_2_10_14_2
  doi: 10.1016/j.jpeds.2011.03.004
– ident: e_1_2_10_15_2
  doi: 10.1053/jpsu.2001.21600
– ident: e_1_2_10_3_2
  doi: 10.1067/mpd.2002.126001
– ident: e_1_2_10_12_2
  doi: 10.1007/s00383-012-3139-x
– ident: e_1_2_10_25_2
  doi: 10.1148/rg.283055108
– ident: e_1_2_10_20_2
  doi: 10.1111/j.1478-3231.2011.02578.x
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Snippet ABSTRACT Objectives: Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with...
OBJECTIVES:Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary...
Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary atresia (BA)....
OBJECTIVESSurveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with biliary...
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SubjectTerms alpha-Fetoproteins - metabolism
alpha‐fetoprotein
biliary atresia
Biliary Atresia - complications
Biliary Atresia - surgery
children
Female
Follow-Up Studies
hepatoblastoma
Hepatoblastoma - blood
Hepatoblastoma - diagnosis
Hepatoblastoma - epidemiology
Hepatoblastoma - etiology
Humans
Infant
Infant, Newborn
Liver Neoplasms - blood
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Liver Neoplasms - etiology
Liver Transplantation
Male
Prevalence
Retrospective Studies
Risk Factors
Sensitivity and Specificity
Title Hepatoblastoma in Explanted Livers of Patients With Biliary Atresia
URI https://onlinelibrary.wiley.com/doi/abs/10.1097%2FMPG.0000000000001167
https://www.ncbi.nlm.nih.gov/pubmed/27457778
https://search.proquest.com/docview/1807278884
Volume 63
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