Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

• Published in: Angewandte Chemie International Edition Vol. 56; no. 52; pp. 16669 - 16673
• Main Authors: Yu, Jiao, Lin, Jin‐Hong, Xiao, Ji‐Chang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 22.12.2017; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Amines; Chemistry; Chemistry, Multidisciplinary; difluorocarbene; difluoromethylthiolation; Fluorides; fluorine; Physical Sciences; Science & Technology; thiocarbonyl fluoride; REAGENT; thiocarbonyl fluoride; DIFLUOROMETHYLENE PHOSPHABETAINE; LIGHT; amines; difluoromethylthiolation; FLUORINATION; SALTS; difluorocarbene; DERIVATIVES; N-TRIFLUOROMETHYLATION; SULFUR-TETRAFLUORIDE; IN-SITU; fluorine; HETEROCYCLIC-COMPOUNDS

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o‐phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively....