Safety, Pharmacokinetics, and Mosquito‐Lethal Effects of Ivermectin in Combination With Dihydroartemisinin‐Piperaquine and Primaquine in Healthy Adult Thai Subjects

• Published in: Clinical pharmacology and therapeutics Vol. 107; no. 5; pp. 1221 - 1230
• Main Authors: Kobylinski, Kevin C., Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Pantuwatana, Kanchana, Phasomkusolsil, Siriporn, Davidson, Silas A., Winterberg, Markus, Hoglund, Richard M., Mukaka, Mavuto, Pluijm, Rob W., Dondorp, Arjen, Day, Nicholas P.J., White, Nicholas J., Tarning, Joel
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020
• Subjects: Adolescent; Adult; Animals; Anopheles - drug effects; Antimalarials - administration & dosage; Antimalarials - adverse effects; Antimalarials - pharmacokinetics; Artemisinins - administration & dosage; Artemisinins - adverse effects; Artemisinins - pharmacokinetics; Drug Interactions; Drug Therapy, Combination; Female; Humans; Insecticides - administration & dosage; Insecticides - adverse effects; Insecticides - pharmacokinetics; Ivermectin - administration & dosage; Ivermectin - adverse effects; Ivermectin - pharmacokinetics; Malaria - prevention & control; Male; Middle Aged; Primaquine - administration & dosage; Primaquine - adverse effects; Primaquine - pharmacokinetics; Quinolines - administration & dosage; Quinolines - adverse effects; Quinolines - pharmacokinetics; Thailand; Young Adult; Thailand

Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics, and mosquito‐lethal effects of combinations of ivermectin, dihydroartemisinin‐piperaquine, and primaquine were evaluated. Coadmi...