Asymmetric Dearomatization of Indole Derivatives with N‐Hydroxycarbamates Enabled by Photoredox Catalysis

• Published in: Angewandte Chemie International Edition Vol. 58; no. 50; pp. 18069 - 18074
• Main Authors: Cheng, Yuan‐Zheng, Zhao, Qing‐Ru, Zhang, Xiao, You, Shu‐Li
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 09.12.2019; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Amines; asymmetric synthesis; Asymmetry; Catalysis; Chemistry; Chemistry, Multidisciplinary; dearomatization; Derivatives; Electron transfer; Heterocyclic compounds; Indoles; Nucleophiles; Phosphoric acid; photochemistry; Photoredox catalysis; Physical Sciences; Science & Technology; umpolung; BRONSTED ACID; ANION PHASE-TRANSFER; ENANTIOSELECTIVE SYNTHESIS; OXIDATIVE DEAROMATIZATION; dearomatization; umpolung; PYRROLOINDOLINES; indoles; asymmetric synthesis; photochemistry; PHOSPHORIC-ACID; CONSTRUCTION; RECENT PROGRESS; METAL CATALYSIS; CYCLIZATION

Dearomatization of indoles provides efficient synthetic routes for substituted indolines. In most cases, indoles serve as nucleophiles. Reported here is an asymmetric dearomatization reaction of indole derivatives that function as electrophiles. The combination of a photocatalyst and chiral phosphor...