Novel High‐Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study

• Published in: Journal of cellular and molecular medicine Vol. 29; no. 11; pp. e70614 - n/a
• Main Authors: Sun, Yuxin, Zhang, Ziran, Chen, Zejun, Li, Zhengran, Wang, Zijin, Wu, Fanye, Ma, Xinyu, Wang, Shaoyu, Cao, Mingzhe, Yi, Guoguo, Fu, Min
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2025; John Wiley and Sons Inc
• Subjects: Biobanks; Biomarkers; Biomarkers - metabolism; Causality; Cholesterol; circulating inflammatory protein; Diabetes; Diabetes mellitus; Diabetic retinopathy; Diabetic Retinopathy - diagnosis; Diabetic Retinopathy - genetics; Diabetic Retinopathy - metabolism; Genome-Wide Association Study; Genomes; Growth factors; High density lipoprotein; Humans; Inflammation; interleukin‐10; Lipid metabolism; Lipid Metabolism - genetics; lipidome; Lipidomics - methods; Lipids; Lipoproteins; mediation analysis; Mendelian randomization; Mendelian Randomization Analysis - methods; Metabolism; Original; Pathogenesis; Polymorphism, Single Nucleotide; Proteins; Retinopathy; shotgun lipidomics technique; triacylglycerol; Variables; mediation analysis; triacylglycerol; circulating inflammatory protein; interleukin‐10; Mendelian randomization; lipidome; shotgun lipidomics technique; diabetic retinopathy

ABSTRACT Although lipid metabolism is a critical factor in the pathogenesis of diabetic retinopathy (DR), the connection between lipidome and DR is still a subject of debate. We aimed to demonstrate that lipidome could serve as novel biomarkers for DR and elucidate the mediating role of inflammatory...