Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years

• Published in: Clinical pharmacology and therapeutics Vol. 107; no. 5; p. 1149
• Main Authors: Zhang, Haeyoung, Basit, Abdul, Wolford, Chris, Chen, Kuan-Fu, Gaedigk, Andrea, Lin, Yvonne S, Leeder, J Steven, Prasad, Bhagwat
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020
• Subjects: Adolescent; Age Factors; Biomarkers - urine; Child; DNA Copy Number Variations; Female; Glucuronosyltransferase - genetics; Humans; Liver - metabolism; Male; Metabolomics; Minor Histocompatibility Antigens - genetics; Polymorphism, Single Nucleotide; Sex Factors; Testosterone - analogs & derivatives; Testosterone - urine
• ISSN: 1532-6535
• DOI: 10.1002/cpt.1764

UDP-glucuronosyltransferase 2B17 (UGT2B17) is a highly variable androgen-metabolizing and drug-metabolizing enzyme. UGT2B17 exhibits a unique ontogeny profile characterized by a dramatic increase in hepatic protein expression from prepubertal age to adulthood. Age, sex, copy number variation (CNV),...