Integrating Flexible Electrochemical Sensor into Microfluidic Chip for Simulating and Monitoring Vascular Mechanotransduction

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 16; no. 9; pp. e1903204 - n/a
• Main Authors: Jin, Zi‐He, Liu, Yan‐Ling, Fan, Wen‐Ting, Huang, Wei‐Hua
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2020
• Subjects: Biomechanics; Blood flow; Blood pressure; Blood vessels; Chemical sensors; electrochemical detection; Electrochemistry; Endothelial Cells; Endothelium; Flexible components; Hemodynamics; Homeostasis; Humans; mechanotransduction; Mechanotransduction, Cellular; microfluidic chips; Microfluidics; Microfluidics - instrumentation; Monitoring; Monitoring, Physiologic - instrumentation; Monitoring, Physiologic - methods; Nanotechnology; Nitric oxide; Nitric Oxide - blood; Organs; Parameters; Physiology; Reactive Oxygen Species - blood; Sensors; Simulation; stretchable sensors; stretchable sensors; electrochemical detection; endothelial cells; microfluidic chips; mechanotransduction

As an interface between the blood flow and vessel wall, endothelial cells (ECs) are exposed to hemodynamic forces, and the biochemical molecules released from ECs–blood flow interaction are important determinants of vascular homeostasis. Versatile microfluidic chips have been designed to simulate th...