Pharmaceutical prokinetic and surgical interventions have opposing effects on gastroduodenal electromechanical coupling

• Published in: Acta Physiologica Vol. 241; no. 5; pp. e70024 - n/a
• Main Authors: Simmonds, Sam, Wang, Tim H.‐H., Matthee, Ashton, Dowrick, Jarrah M., Taberner, Andrew J., Du, Peng, Angeli‐Gordon, Timothy R.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2025; John Wiley and Sons Inc
• Subjects: Animal models; Animals; Contractility; Duodenum - drug effects; Duodenum - physiology; electrophysiology; Erythromycin; Erythromycin - pharmacology; Female; Gastric emptying; Gastric Emptying - drug effects; Gastric Emptying - physiology; Gastrointestinal Agents - pharmacology; Gastrointestinal diseases; Gastrointestinal Motility - drug effects; Gastrointestinal Motility - physiology; in vivo experimentation; motility; prokinetics; Research Paper; slow waves; Stomach - drug effects; Stomach - physiology; Swine; Vagotomy; in vivo experimentation; slow waves; motility; prokinetics; electrophysiology; vagotomy

Improper gastric emptying is implicated in several gastrointestinal disorders and may result from disrupted electromechanical coupling of the gastroduodenal junction (GDJ). Rhythmic “slow waves” and myogenic “spikes” are bioelectrical mechanisms that, alongside neural and hormonal co‐factors, contro...