Synthesis and Derivatization of 1,1‐[18F]Difluorinated Alkenes

• Published in: Angewandte Chemie International Edition Vol. 58; no. 2; pp. 472 - 476
• Main Authors: Frost, Aileen B., Brambilla, Marta, Exner, Rüdiger M., Tredwell, Matthew
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.01.2019; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkenes; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Fluorides; Fluorination; Fluorine; fluorine-18; Functional groups; Physical Sciences; positron emission tomography; Radiochemistry; Science & Technology; DRUG; DESIGN; ARENES; fluorination; F-18; IODIDES; fluorine-18; POSITRON-EMISSION-TOMOGRAPHY; RADIOSYNTHESIS; ARYL; INHIBITORS; positron emission tomography; BRAIN; fluorine

A general method for the synthesis of 1,1‐[18F]difluorinated alkenes from [18F]fluoride is reported. This transformation is highly regioselective giving the desired 18F‐fluoroalkenes with radiochemical purities of up to 77 % within 20 minutes and a molar activity (Am) of 1 GBq μmol−1. The transforma...