Titanocene‐Catalyzed Radical Opening of N‐Acylated Aziridines

• Published in: Angewandte Chemie International Edition Vol. 56; no. 41; pp. 12654 - 12657
• Main Authors: Zhang, Yong‐Qiang, Vogelsang, Elisabeth, Qu, Zheng‐Wang, Grimme, Stefan, Gansäuer, Andreas
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 02.10.2017; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Acylation; aziridines; Catalysis; Chemistry; Chemistry, Multidisciplinary; conjugate addition; Electron transfer; Physical Sciences; radical ring opening; reduction; Ring opening; Science & Technology; titanocenes; aziridines; AUXILIARY BASIS-SETS; EPOXIDE; conjugate addition; radical ring opening; ELECTRON-TRANSFER; ZETA VALENCE QUALITY; titanocenes; ATOMS; AMINOKETYL RADICALS; reduction; AMIDE BOND; UMPOLUNG; CYCLIZATION

Aziridines activated by N‐acylation are opened to the higher substituted radical through electron transfer from titanocene(III) complexes in a novel catalytic reaction. This reaction is applicable in conjugate additions, reductions, and cyclizations and suited for the construction of quaternary carb...