In vitro and in vivo techniques used in drug development for evaluation of dose delivery of inhaled corticosteroids

• Published in: Journal of clinical pharmacology Vol. 41; no. 1; p. 7
• Main Authors: Rhodes, G R, Rohatagi, S, Gillen, M S, Deluccia, F, Banerji, D D, Chaikin, P
• Format: Journal Article
• Language: English
• Published: England 01.01.2001
• Subjects: Absorption - drug effects; Administration, Inhalation; Adult; Aerosol Propellants - administration & dosage; Aerosols; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacokinetics; Charcoal - pharmacology; Chemistry, Pharmaceutical; Child; Clinical Trials as Topic; Drug Delivery Systems; Humans; Nebulizers and Vaporizers; Particle Size; Triamcinolone Acetonide - administration & dosage; Triamcinolone Acetonide - pharmacokinetics

Oral inhaled corticosteroids are important in the treatment of asthma since their delivery is targeted directly to the lung, which is the site of action. Triamcinolone acetonide (TAA) is an effective and safe corticosteroid that is marketed as a metered-dose inhaler (MDI) with an integrated spacer (...