Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study
The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to recei...
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Published in | The journal of nervous and mental disease Vol. 201; no. 4; p. 266 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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United States
01.04.2013
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Abstract | The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to receive venlafaxine extended release (ER; 75-300 mg/day) or fluoxetine (20-60 mg/day). Sexual dysfunction was assessed using items from the 17-item Hamilton Rating Scale for Depression (HAM-D(17)) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR). The baseline rates of sexual dysfunction based on the HAM-D(17) and IDS-SR items were 57.9% and 48.8%, respectively. The rates of new-onset sexual dysfunction for the venlafaxine ER-treated (44.8%, HAM-D(17); 38.4%, IDS-SR) and fluoxetine-treated patients (52.9%, HAM-D(17); 50.0%, IDS-SR) were similar; approximately 80% of the cases resolved during treatment. Treatment response was associated with lower rates of new-onset sexual dysfunction compared with nonresponse. The patients who remitted were the least likely to experience sexual dysfunction during antidepressant treatment. |
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AbstractList | The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to receive venlafaxine extended release (ER; 75-300 mg/day) or fluoxetine (20-60 mg/day). Sexual dysfunction was assessed using items from the 17-item Hamilton Rating Scale for Depression (HAM-D(17)) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR). The baseline rates of sexual dysfunction based on the HAM-D(17) and IDS-SR items were 57.9% and 48.8%, respectively. The rates of new-onset sexual dysfunction for the venlafaxine ER-treated (44.8%, HAM-D(17); 38.4%, IDS-SR) and fluoxetine-treated patients (52.9%, HAM-D(17); 50.0%, IDS-SR) were similar; approximately 80% of the cases resolved during treatment. Treatment response was associated with lower rates of new-onset sexual dysfunction compared with nonresponse. The patients who remitted were the least likely to experience sexual dysfunction during antidepressant treatment. |
Author | Gelenberg, Alan J Dunner, David L Dorries, Kathleen M Pedersen, Ron Rothschild, Anthony J Ninan, Philip T |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23538970$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adolescent Adult Aged Aged, 80 and over Antidepressive Agents, Second-Generation - adverse effects Antidepressive Agents, Second-Generation - therapeutic use Cyclohexanols - adverse effects Cyclohexanols - therapeutic use Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - psychology Double-Blind Method Female Fluoxetine - adverse effects Fluoxetine - therapeutic use Follow-Up Studies Humans Male Middle Aged Personality Inventory - statistics & numerical data Psychometrics Secondary Prevention Sexual Dysfunction, Physiological - chemically induced Sexual Dysfunction, Physiological - diagnosis Sexual Dysfunction, Physiological - psychology Treatment Outcome United States Venlafaxine Hydrochloride Young Adult |
Title | Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study |
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