Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study

The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to recei...

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Published inThe journal of nervous and mental disease Vol. 201; no. 4; p. 266
Main Authors Gelenberg, Alan J, Dunner, David L, Rothschild, Anthony J, Pedersen, Ron, Dorries, Kathleen M, Ninan, Philip T
Format Journal Article
LanguageEnglish
Published United States 01.04.2013
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Abstract The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to receive venlafaxine extended release (ER; 75-300 mg/day) or fluoxetine (20-60 mg/day). Sexual dysfunction was assessed using items from the 17-item Hamilton Rating Scale for Depression (HAM-D(17)) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR). The baseline rates of sexual dysfunction based on the HAM-D(17) and IDS-SR items were 57.9% and 48.8%, respectively. The rates of new-onset sexual dysfunction for the venlafaxine ER-treated (44.8%, HAM-D(17); 38.4%, IDS-SR) and fluoxetine-treated patients (52.9%, HAM-D(17); 50.0%, IDS-SR) were similar; approximately 80% of the cases resolved during treatment. Treatment response was associated with lower rates of new-onset sexual dysfunction compared with nonresponse. The patients who remitted were the least likely to experience sexual dysfunction during antidepressant treatment.
AbstractList The incidence of treatment-emergent sexual dysfunction in the acute and continuation phases of the prevention of recurrent episodes of depression with venlafaxine ER for two years (PREVENT) study was assessed. Adult outpatients with recurrent major depressive disorder were randomly assigned to receive venlafaxine extended release (ER; 75-300 mg/day) or fluoxetine (20-60 mg/day). Sexual dysfunction was assessed using items from the 17-item Hamilton Rating Scale for Depression (HAM-D(17)) and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR). The baseline rates of sexual dysfunction based on the HAM-D(17) and IDS-SR items were 57.9% and 48.8%, respectively. The rates of new-onset sexual dysfunction for the venlafaxine ER-treated (44.8%, HAM-D(17); 38.4%, IDS-SR) and fluoxetine-treated patients (52.9%, HAM-D(17); 50.0%, IDS-SR) were similar; approximately 80% of the cases resolved during treatment. Treatment response was associated with lower rates of new-onset sexual dysfunction compared with nonresponse. The patients who remitted were the least likely to experience sexual dysfunction during antidepressant treatment.
Author Gelenberg, Alan J
Dunner, David L
Dorries, Kathleen M
Pedersen, Ron
Rothschild, Anthony J
Ninan, Philip T
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StartPage 266
SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Cyclohexanols - adverse effects
Cyclohexanols - therapeutic use
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - psychology
Double-Blind Method
Female
Fluoxetine - adverse effects
Fluoxetine - therapeutic use
Follow-Up Studies
Humans
Male
Middle Aged
Personality Inventory - statistics & numerical data
Psychometrics
Secondary Prevention
Sexual Dysfunction, Physiological - chemically induced
Sexual Dysfunction, Physiological - diagnosis
Sexual Dysfunction, Physiological - psychology
Treatment Outcome
United States
Venlafaxine Hydrochloride
Young Adult
Title Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study
URI https://www.ncbi.nlm.nih.gov/pubmed/23538970
Volume 201
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