Comparison of Transcranial Sonography and [18F]‐Fluorodopa PET Imaging in GBA1 Mutation Carriers

• Published in: Movement disorders Vol. 37; no. 3; pp. 629 - 634
• Main Authors: Eisenberg, Daniel P., Lopez, Grisel, Gregory, Michael D., Berman, Karen F., Sidransky, Ellen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2022; Wiley Subscription Services, Inc
• Subjects: 18F‐fluorodopa PET imaging; Basal ganglia; Brain diseases; Central nervous system diseases; Dihydroxyphenylalanine - analogs & derivatives; Dopamine; Gaucher disease; glucocerebrosidase; Glucosylceramidase - genetics; Humans; Movement disorders; Mutation; Mutation - genetics; Neostriatum; Parkinsonian Disorders - genetics; parkinsonism; Patients; Positron-Emission Tomography - methods; Risk factors; Substantia nigra; transcranial sonography; Ultrasonic imaging; Ultrasonography; 18F-fluorodopa PET imaging; Gaucher disease; parkinsonism; glucocerebrosidase; transcranial sonography

Background Mutations in GBA1 are a common genetic risk factor for parkinsonism; however, penetrance is incomplete, and biomarkers of future progression to parkinsonism are needed. Both nigral sonography and striatal [18F]‐FDOPA PET assay dopamine system health, but their utility and coherence in thi...