Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation

• Published in: Angewandte Chemie International Edition Vol. 57; no. 51; pp. 16754 - 16759
• Main Authors: Zhang, Sainan, Zheng, Yunlong, An, Hongde, Aguila, Briana, Yang, Cheng‐Xiong, Dong, Yueyue, Xie, Wei, Cheng, Peng, Zhang, Zhenjie, Chen, Yao, Ma, Shengqian
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 17.12.2018
• Edition: International ed. in English
• Subjects: Amino acids; Biomolecules; chiral separation; chiral stationary phases; Chirality; Covalence; covalent organic frameworks; Enzymes; High performance liquid chromatography; Liquid chromatography; Peptides; Pharmacology; Protein structure; Raman spectra; Secondary structure; Separation; covalent organic frameworks; chiral separation; chirality; biomolecules; chiral stationary phases

The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent...