Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation
The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent...
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| Published in | Angewandte Chemie International Edition Vol. 57; no. 51; pp. 16754 - 16759 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Wiley Subscription Services, Inc
17.12.2018
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| Edition | International ed. in English |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high‐performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface‐enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs.
COF chirality: A general and efficient strategy has been developed to introduce chirality into covalent organic frameworks (COFs) by covalently immobilizing biomolecules into achiral COFs. The biomolecules⊂COFs can serve as chiral stationary phases for efficient chiral separation of a broad range of racemates. |
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| AbstractList | The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high-performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface-enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs. The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high‐performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface‐enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs. COF chirality: A general and efficient strategy has been developed to introduce chirality into covalent organic frameworks (COFs) by covalently immobilizing biomolecules into achiral COFs. The biomolecules⊂COFs can serve as chiral stationary phases for efficient chiral separation of a broad range of racemates. The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high-performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface-enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs.The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high-performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface-enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs. |
| Author | Zhang, Sainan Dong, Yueyue Yang, Cheng‐Xiong An, Hongde Zhang, Zhenjie Xie, Wei Cheng, Peng Zheng, Yunlong Aguila, Briana Chen, Yao Ma, Shengqian |
| Author_xml | – sequence: 1 givenname: Sainan surname: Zhang fullname: Zhang, Sainan organization: Nankai University – sequence: 2 givenname: Yunlong surname: Zheng fullname: Zheng, Yunlong organization: Nankai University – sequence: 3 givenname: Hongde surname: An fullname: An, Hongde organization: Nankai University – sequence: 4 givenname: Briana surname: Aguila fullname: Aguila, Briana organization: University of South Florida – sequence: 5 givenname: Cheng‐Xiong surname: Yang fullname: Yang, Cheng‐Xiong organization: Nankai University – sequence: 6 givenname: Yueyue surname: Dong fullname: Dong, Yueyue organization: Nankai University – sequence: 7 givenname: Wei surname: Xie fullname: Xie, Wei organization: Nankai University – sequence: 8 givenname: Peng surname: Cheng fullname: Cheng, Peng organization: Nankai University – sequence: 9 givenname: Zhenjie surname: Zhang fullname: Zhang, Zhenjie email: zhangzhenjie@nankai.edu.cn organization: Nankai University – sequence: 10 givenname: Yao surname: Chen fullname: Chen, Yao email: chenyao@nankai.edu.cn organization: Nankai University – sequence: 11 givenname: Shengqian orcidid: 0000-0002-1897-7069 surname: Ma fullname: Ma, Shengqian email: sqma@usf.edu organization: University of South Florida |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30359485$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Amino acids Biomolecules chiral separation chiral stationary phases Chirality Covalence covalent organic frameworks Enzymes High performance liquid chromatography Liquid chromatography Peptides Pharmacology Protein structure Raman spectra Secondary structure Separation |
| Title | Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation |
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