Guanitrypmycin Biosynthetic Pathways Imply Cytochrome P450 Mediated Regio‐ and Stereospecific Guaninyl‐Transfer Reactions

• Published in: Angewandte Chemie International Edition Vol. 58; no. 33; pp. 11534 - 11540
• Main Authors: Liu, Jing, Xie, Xiulan, Li, Shu‐Ming
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 12.08.2019
• Edition: International ed. in English
• Subjects: Alkaloids; Biocatalysts; biosynthesis; Cultivation; cyclodipeptides; Cytochrome; Cytochrome P450; Cytochromes P450; Enzymes; Gene clusters; Gene expression; Genomes; guaninyl transferase; Indoles; Microorganisms; Natural products; Tautomerism; natural products; cytochrome P450; guaninyl transferase; cyclodipeptides; biosynthesis

Mining microbial genomes including those of Streptomyces reveals the presence of a large number of biosynthetic gene clusters. Unraveling this genetic potential has proved to be a useful approach for novel compound discovery. Here, we report the heterologous expression of two similar P450‐associated...