A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

• Published in: Macromolecular bioscience Vol. 19; no. 8; pp. e1900071 - n/a
• Main Authors: Kumar, Parveen, Liu, Bo, Behl, Gautam
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2019
• Subjects: Animals; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Biomedical materials; Cell Line, Tumor; Chemical modification; Chemical synthesis; Cross-Linking Reagents - chemistry; Disease Models, Animal; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Fabrication; Functional groups; glutathione; Humans; Hydrogen-Ion Concentration; nanogels; Nanogels - administration & dosage; Nanogels - chemistry; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Neoplasms - drug therapy; Neoplasms - pathology; Organic chemistry; Oxidation-Reduction; Oxidative stress; Pathogenesis; pH responsive; Polymerization; Polymers - chemical synthesis; Polymers - pharmacokinetics; Redox potential; redox responsive; ROS responsive; Stimuli; Temperature; ROS responsive; redox responsive; glutathione; nanogels; pH responsive

Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable...