Molecular Targeting‐Mediated Mild‐Temperature Photothermal Therapy with a Smart Albumin‐Based Nanodrug

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 15; no. 33; pp. e1900501 - n/a
• Main Authors: Gao, Ge, Jiang, Yao‐Wen, Sun, Wei, Guo, Yuxin, Jia, Hao‐Ran, Yu, Xin‐Wang, Pan, Guang‐Yu, Wu, Fu‐Gen
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2019
• Subjects: Ablation; Accumulation; Anticancer properties; Charge reversal; Chemotherapy; combination therapy; Cyanine dyes; degradability; Disruption; Heat shock proteins; Hyperthermia; Infrared lasers; Liver; mild‐temperature photothermal therapy; Mitochondria; molecularly targeted therapy; Nanoparticles; Nanotechnology; Organs; pH‐responsive charge reversal; Serum albumin; Tumors; combination therapy; degradability; mild-temperature photothermal therapy; pH-responsive charge reversal; molecularly targeted therapy

Photothermal therapy (PTT) usually requires hyperthermia >50 °C for effective tumor ablation, which inevitably induces heating damage to the surrounding normal tissues/organs. Moreover, low tumor retention and high liver accumulation are the two main obstacles that significantly limit the efficac...