Palladium‐Catalyzed Defluorinative Alkylation of gem‐Difluorocyclopropanes: Switching Regioselectivity via Simple Hydrazones

• Published in: Angewandte Chemie International Edition Vol. 60; no. 23; pp. 13098 - 13104
• Main Authors: Lv, Leiyang, Li, Chao‐Jun
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.06.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aldehydes; Alkylation; Chemistry; Chemistry, Multidisciplinary; Couplings; defluorination; Denitrogenation; fluoroalkenes; gem-difluorocyclopropane; Hydrazones; Nucleophiles; Palladium; Physical Sciences; Regioselectivity; Science & Technology; Selectivity; fluoroalkenes; alkylation; defluorination; gem-difluorocyclopropane; hydrazones

Conventional approaches for Pd‐catalyzed ring‐opening cross‐couplings of gem‐difluorocyclopropanes with nucleophiles predominantly deliver the β‐fluoroalkene scaffolds (linear selectivity). Herein, we report a cooperative strategy that can completely switch the reaction selectivity to give the alkyl...