Race-related host and microbe transcriptomic signatures in triple-negative breast cancer

• Published in: NPJ breast cancer Vol. 11; no. 1; pp. 87 - 10
• Main Authors: Kumar, Roshan, Duyar-Ayerdi, Susan, Sundaresan, Aishwarya, Srinivasasainagendra, Vinodh, Pedamallu, Chandra Sekhar, Behring, Michael, Chandrashekar, Darshan Shimoga, Eltoum, Isam-Eldin, Varambally, Sooryanarayana, Tiwari, Hemant K., Shrestha, Sadeep, Auer, Paul L., Chaudhary, Lubna N., Kirby, John R., Yates, Clayton, Manne, Upender, Ojesina, Akinyemi I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326; 631/67/69; 692/699/67/1347; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cancer Research; Cancer therapies; Cell Biology; Chemotherapy; Cluster analysis; Gene expression; Human Genetics; Metastasis; Mortality; Oncology; Race; Radiation; RNA polymerase; Tumors; Womens health

Triple-negative breast cancer (TNBC) shows racial disparities, with higher incidence in women of African ancestry (AA) compared to European ancestry (EA). Meta-transcriptomic analysis of TNBC tumor tissues from AA (n = 17) and EA (n = 19) subjects revealed distinct microbial landscapes. Hierarchical...