A novel approach to smart-assisted schizophrenia screening based on Raman spectroscopy and deep learning

• Published in: Scientific reports Vol. 15; no. 1; pp. 28487 - 11
• Main Authors: Xiao, Meng, Xiaokaiti, Sulidan, Shang, Meng, Xu, Pan, Zhu, Xiaofen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/443; 631/45; 639/624; 692/308; 692/617; 692/699; Adult; Biomarkers; Body fluids; Carotenoids; Deep Learning; Disease; Female; Health care; Humanities and Social Sciences; Humans; Lipids; Male; Markov Chains; Medical diagnose; Medical screening; Mental disorders; Methods; multidisciplinary; Neural networks; Neural Networks, Computer; Proteins; Raman spectroscopy; Schizophrenia; Schizophrenia - blood; Schizophrenia - diagnosis; Science; Science (multidisciplinary); Signal processing; Spectral analysis; Spectrum analysis; Spectrum Analysis, Raman - methods; Time series; Triglycerides; Deep learning; Schizophrenia; Medical diagnose; Raman spectroscopy

In this study, serum Raman spectra are introduced into the screening of schizophrenia. We collect serum Raman spectra from schizophrenic and healthy individuals, classified them based on four convolutional neural networks, and developed an assisted screening method for schizophrenia based on serum R...