Synthesis of 4-(4-chlorophenyl)thiazole compounds: in silico and in vitro evaluations as leishmanicidal and trypanocidal agents

• Published in: Anais da Academia Brasileira de Ciências Vol. 95; no. 1; p. e20220538
• Main Authors: Cruz Filho, Iranildo José DA, Oliveira, Jamerson F DE, Santos, Aline Caroline S, Pereira, Valéria R A, Lima, Maria Carmo A DE
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Ciências 01.01.2023
• Subjects: Animals; antiparasitic; Antiparasitic Agents - pharmacology; Chagas Disease - drug therapy; compounds; Leishmania amazonensis; Leishmania mexicana; MULTIDISCIPLINARY SCIENCES; Trypanocidal Agents - pharmacology; Trypanosoma cruzi; antiparasitic; compounds; Leishmania amazonensis; Trypanosoma cruzi

Neglected tropical diseases are a diverse group of communicable pathologies that mainly prevail in tropical and subtropical regions. Thus, the objective of this work was to evaluate the biological potential of eight 4-(4-chlorophenyl)thiazole compounds. Tests were carried out in silico to evaluate t...