Platelet-Derived Thrombospondin-1 Is Necessary for the Vitamin D-Binding Protein (Gc-Globulin) to Function as a Chemotactic Cofactor for C5a

• Published in: The Journal of immunology (1950) Vol. 173; no. 6; pp. 4130 - 4136
• Main Authors: Trujillo, Glenda, Kew, Richard R
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.09.2004
• Subjects: Adjuvants, Immunologic - isolation & purification; Adjuvants, Immunologic - physiology; Blood Platelets - physiology; Chemotactic Factors - isolation & purification; Chemotactic Factors - physiology; Chemotaxis, Leukocyte - physiology; Complement Activation - immunology; Complement C5a - metabolism; Complement C5a - physiology; Humans; Neutrophils - physiology; Platelet Activation - immunology; Receptor, Anaphylatoxin C5a - genetics; Receptor, Anaphylatoxin C5a - physiology; Thrombospondin 1 - isolation & purification; Thrombospondin 1 - physiology; Transfection; U937 Cells; Vitamin D-Binding Protein - blood; Vitamin D-Binding Protein - physiology

The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin. DBP is a multifunctional 56-kDa plasma protein that binds and transports several diverse ligands. The objective of this study was to investigate the mechan...