The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

• Published in: Nature (London) Vol. 549; no. 7671; pp. 282 - 286
• Main Authors: Klose, Christoph S. N., Mahlakõiv, Tanel, Moeller, Jesper B., Rankin, Lucille C., Flamar, Anne-Laure, Kabata, Hiroki, Monticelli, Laurel A., Moriyama, Saya, Putzel, Gregory Garbès, Rakhilin, Nikolai, Shen, Xiling, Kostenis, Evi, König, Gabriele M., Senda, Takashi, Carpenter, Dustin, Farber, Donna L., Artis, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.09.2017; Nature Publishing Group
• Subjects: 13/31; 14/19; 14/63; 38/1; 38/91; 631/250/2504/2506; 631/250/347; 631/250/371; 64/60; Adaptive immunity; Adoptive Transfer; Animals; Antiinfectives and antibacterials; Cell activation; Cholinergic Neurons - drug effects; Cholinergic Neurons - metabolism; Cytokines; Cytokines - immunology; Cytokines - metabolism; Enteric nervous system; Eosinophils - cytology; Eosinophils - drug effects; Eosinophils - immunology; Female; Gastrointestinal tract; Gastrointestinal Tract - cytology; Gastrointestinal Tract - immunology; Gastrointestinal Tract - innervation; Genomics; GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism; Homeostasis; Humanities and Social Sciences; Hypersensitivity; Immune response; Immune system; Immunity, Innate - drug effects; In vitro methods and tests; Inflammation; Inflammation - chemically induced; Inflammation - immunology; Inflammation - pathology; Innate immunity; Interleukin 13; Interleukin 5; Interleukin 9; Interleukin-13 - immunology; Interleukin-13 - metabolism; Interleukin-5 - immunology; Interleukin-5 - metabolism; Interleukin-9 - immunology; Interleukin-9 - metabolism; Intestinal parasites; letter; Leukocytes (eosinophilic); Ligands; Lungs; Lymphocytes - cytology; Lymphocytes - drug effects; Lymphocytes - immunology; Lymphoid cells; Male; Mice; Microorganisms; Mucosa; multidisciplinary; Nervous system; Neuromedin; Neurons; Neuropeptides; Neuropeptides - metabolism; Neuropeptides - pharmacology; Nippostrongylus - immunology; Pneumonia - chemically induced; Pneumonia - immunology; Pneumonia - pathology; Proteins; Receptors, Neurotransmitter - deficiency; Receptors, Neurotransmitter - genetics; Receptors, Neurotransmitter - metabolism; Science; Signal Transduction - drug effects; Signaling; Small intestine

Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type 2 cytokine response and accelerated expulsion of the gastro-intestinal nematode Nippostrongylus brasiliensis . Neuron regulation of immune c...