A multi-model approach to nucleic acid-based drug development

• Published in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy Vol. 18; no. 1; pp. 37 - 50
• Main Authors: Gautherot, Isabelle, Sodoyer, Regís
• Format: Journal Article
• Language: English
• Published: New Zealand Wolters Kluwer Health, Inc 2004
• Subjects: Animals; Drug Design; Humans; Models, Biological; Models, Chemical; Nucleic Acids - chemical synthesis; Nucleic Acids - therapeutic use; Technology, Pharmaceutical - methods

With the advent of functional genomics and the shift of interest towards sequence-based therapeutics, the past decades have witnessed intense research efforts on nucleic acid-mediated gene regulation technologies. Today, RNA interference is emerging as a groundbreaking discovery, holding promise for...