Pityriasis rosea-like drug eruption due to bupropion A case report

• Published in: Human & experimental toxicology Vol. 33; no. 12; pp. 1294 - 1296
• Main Authors: Polat, M., Uzun, Ö., Örs, İ., Boran, Ç.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2014; Sage Publications; Sage Publications Ltd
• Subjects: Antidepressants; Antidepressive Agents, Second-Generation - adverse effects; Autoimmune diseases; Autoimmunity; Biological and medical sciences; Bupropion; Bupropion - adverse effects; Dermatology; Disease control; Dopamine Uptake Inhibitors - adverse effects; Drug Eruptions - etiology; Drugs; Eruptions; Female; Humans; Hypersensitivity; Medical sciences; Middle Aged; Pityriasis; Pityriasis Rosea - chemically induced; Skin diseases; Skin involvement in other diseases. Miscellaneous. General aspects; Smoking Cessation; Studies; Tension; Toxicity; Toxicology; bupropion; drug eruption; Pityriasis rosea; Infection; Case study; Human; Drug; Skin disease; Bupropion; Psychotropic; Presumed viral disease
• DOI: 10.1177/0960327113478444
• ISSN: 0960-3271

Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary “herald” patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is a well-known and relatively common disease, its cause is still not completely understood. However, viral agents, autoimmunity, psychogenic status, and numerous drugs have been proposed as possible factors to PR. Bupropion is known to cause hypersensitivity reactions. We present a clinical case of PR eruption caused by the use of bupropion. To the best of our knowledge, this is the first published case of PR associated with bupropion use.