Advances in Catalytic C–F Bond Activation and Transformation of Aromatic Fluorides

The activation and transformation of C–F bonds in fluoro-aromatics is a highly desirable process in organic chemistry. It provides synthetic methods/protocols for the generation of organic compounds possessing single or multiple C–F bonds, and effective catalytic systems for further study of the act...

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Bibliographic Details
Published inCatalysts Vol. 12; no. 12; p. 1665
Main Authors Ma, Rongqing, Hu, Hongfan, Li, Xinle, Mao, Guoliang, Song, Yuming, Xin, Shixuan
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.12.2022
Subjects
activation
Agricultural chemicals
aromatics
Bond energy
Carbon
Catalysts
catalytic
Chemical bonds
Chemical properties
Chemical reactions
C–F bond
Fine chemicals
Fluorides
Fluorine
Ligands
metal-free
Organic chemistry
Organic compounds
Palladium
Reagents
System effectiveness
Transformations
transition metal
Transition metal compounds
Transition metals
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Summary:The activation and transformation of C–F bonds in fluoro-aromatics is a highly desirable process in organic chemistry. It provides synthetic methods/protocols for the generation of organic compounds possessing single or multiple C–F bonds, and effective catalytic systems for further study of the activation mode of inert chemical bonds. Due to the high polarity of the C–F bond and it having the highest bond energy in organics, C–F activation often faces considerable academic challenges. In this mini-review, the important research achievements in the activation and transformation of aromatic C–F bond, catalyzed by transition metal and metal-free systems, are presented.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal12121665