Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential

Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taur...

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Published inJournal of clinical medicine Vol. 11; no. 3; p. 666
Main Authors Roşca, Adrian Eugen, Vlădăreanu, Ana-Maria, Mirica, Radu, Anghel-Timaru, Cristina-Mihaela, Mititelu, Alina, Popescu, Bogdan Ovidiu, Căruntu, Constantin, Voiculescu, Suzana Elena, Gologan, Şerban, Onisâi, Minodora, Iordan, Iuliana, Zăgrean, Leon
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.01.2022
MDPI
Subjects
Amino acids
Apoptosis
Blood clots
Blood platelets
Brain damage
Cardiovascular disease
Clinical medicine
Drug dosages
Experiments
Ischemia
Mortality
Nervous system
Physiology
Review
Stroke
Thrombosis
United Kingdom > UK
hemostasis/haemostasis
thrombosis
thrombotic diathesis
platelet activity
platelet reactivity
taurine
taurine derivatives/analogues
coagulation
platelet aggregation
prothrombotic state
Online AccessGet full text
ISSN2077-0383
2077-0383
DOI10.3390/jcm11030666

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Abstract Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
AbstractList Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
Author Roşca, Adrian Eugen
Gologan, Şerban
Mirica, Radu
Zăgrean, Leon
Anghel-Timaru, Cristina-Mihaela
Mititelu, Alina
Voiculescu, Suzana Elena
Iordan, Iuliana
Popescu, Bogdan Ovidiu
Căruntu, Constantin
Vlădăreanu, Ana-Maria
Onisâi, Minodora
AuthorAffiliation 8 Department of Medical Semiology and Nephrology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
5 Department of Neurology, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 020125 Bucharest, Romania; bogdan_ovidiu_popescu@yahoo.com
7 Department of Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, Elias Clinical Hospital, 011461 Bucharest, Romania; serbangologan@gmail.com
1 Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; cristina.timaru@umfcd.ro (C.-M.A.-T.); costin.caruntu@gmail.com (C.C.); suzana.voiculescu@umfcd.ro (S.E.V.); leon.zagrean@umfcd.ro (L.Z.)
6 Department of Dermatology, “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania
4 Department of Surgery, “Carol Davila” University of Medicine and Pharmacy, “Sf. Ioan” Clinical Hospital, 042122 Bucharest, Romania; mirica_rm@yahoo.com
2 Depar
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– name: 8 Department of Medical Semiology and Nephrology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
– name: 1 Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; cristina.timaru@umfcd.ro (C.-M.A.-T.); costin.caruntu@gmail.com (C.C.); suzana.voiculescu@umfcd.ro (S.E.V.); leon.zagrean@umfcd.ro (L.Z.)
– name: 3 Department of Hematology, “Carol Davila” University of Medicine and Pharmacy, Emergency University Hospital of Bucharest, 050098 Bucharest, Romania; alina.mititelu@drd.umfcd.ro (A.M.); minodorel@yahoo.com (M.O.); iuliana.iordan@drd.umfcd.ro (I.I.)
– name: 7 Department of Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, Elias Clinical Hospital, 011461 Bucharest, Romania; serbangologan@gmail.com
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Issue 3
Keywords hemostasis/haemostasis
thrombosis
thrombotic diathesis
platelet activity
platelet reactivity
taurine
taurine derivatives/analogues
coagulation
platelet aggregation
prothrombotic state
Language English
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PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Journal of clinical medicine
PublicationTitleAlternate J Clin Med
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid....
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SubjectTerms Amino acids
Apoptosis
Blood clots
Blood platelets
Brain damage
Cardiovascular disease
Clinical medicine
Drug dosages
Experiments
Ischemia
Mortality
Nervous system
Physiology
Review
Stroke
Thrombosis
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Title Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential
URI https://www.ncbi.nlm.nih.gov/pubmed/35160118
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Volume 11
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