Next-generation anti–Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 1; pp. 78 - 81
• Main Authors: Clowry, Julianne, Irvine, Alan D., McLoughlin, Rachel M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019; Elsevier Limited
• Subjects: Adjuvants; Aluminum sulfate; Antibiotics; Antimicrobial agents; Atopic dermatitis; Capsular polysaccharides; Colonization; Dermatitis; Eczema; Immunization (passive); Interleukin 13; Interleukin 4; Leukocidin; Lymphocytes; Lymphocytes T; Monoclonal antibodies; Patients; Peptides; Phenols; Proteins; Risk groups; Skin; Staphylococcus aureus; Streptococcus infections; T cell; vaccine; Vaccines; New York; United States > US; China; atopic dermatitis; vaccine; T cell; Staphylococcus aureus

Disease severity in patients with atopic dermatitis (AD) is directly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for S aureus in the pathogenesis of AD in genetically susceptible subjects.2 Increased prevalence of S aureus preceding...