Insight into the Structure and Function of the Transferrin Receptor from Neisseria meningitidis Using Microcalorimetric Techniques

• Published in: The Journal of biological chemistry Vol. 278; no. 17; pp. 14712 - 14722
• Main Authors: Krell, Tino, Renauld-Mongénie, Geneviève, Nicolaı̈, Marie-Claire, Fraysse, Sophie, Chevalier, Michel, Bérard, Yves, Oakhill, Jonathan, Evans, Robert W., Gorringe, Andrew, Lissolo, Ling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.04.2003; American Society for Biochemistry and Molecular Biology
• Subjects: Bacterial Proteins - chemistry; Bacterial Proteins - physiology; Calorimetry, Differential Scanning; Neisseria meningitidis - chemistry; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Receptors, Transferrin - chemistry; Receptors, Transferrin - metabolism; Receptors, Transferrin - physiology; Thermodynamics; Transferrin-Binding Protein A - metabolism; Transferrin-Binding Protein B - chemistry; Transferrin-Binding Protein B - isolation & purification; Transferrin-Binding Protein B - metabolism

The transferrin receptor of Neisseria meningitidis is composed of the transmembrane protein TbpA and the outer membrane protein TbpB. Both receptor proteins have the capacity to independently bind their ligand human transferrin (htf). To elucidate the specific role of these proteins in receptor func...