Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex - Arasappan, Ashok; Njoroge, F. George; Parekh, Tejal N.; Yang, Xiaozheng; Pichardo, John; Butkiewicz, Nancy; Prongay, Andrew; Yao, Nanhua; Girijavallabhan, Viyyoor (Bioorganic & medicinal chemistry letters, 2004)
Keywords: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Carboxylic Acids - chemical synthesis; Carboxylic Acids - pharmacology; CRYSTAL STRUCTURE; Crystallography, X-Ray - methods; ENZYME INHIBITORS; Hepacivirus - drug effects; Hepacivirus - enzymology; HEPATITIS; Imidazolidines - chemical synthesis; Imidazolidines - pharmacology; MATERIALS SCIENCE; Medical sciences; Pharmacology. Drug treatments; Protein Conformation; SERINE; Serine Endopeptidases - metabolism; Serine Proteinase Inhibitors - chemical synthesis; Serine Proteinase Inhibitors - pharmacology; SYNTHESIS; Viral Nonstructural Proteins - antagonists & inhibitors; Imidazole derivatives; Serine endopeptidases; Enzyme; Inhibitor enzyme complex; Biological activity; Virus; Peptidases; Carboxylic acid; Hydrolases; Antiviral; Ureas; Flaviviridae; Chemical synthesis; Hepatitis C virus; Hepacivirus; Protease inhibitor; Crystalline structure