Farnesyl-diphosphate synthase is localized in peroxisomes

• Published in: The Journal of biological chemistry Vol. 269; no. 19; pp. 14165 - 14169
• Main Authors: KRISANS, S. K, ERICSSON, J, EDWARDS, P. A, KELLER, G.-A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 13.05.1994
• Subjects: Adrenoleukodystrophy - enzymology; Alkyl and Aryl Transferases; Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Centrifugation, Density Gradient; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Geranyltranstransferase; Humans; Liver - enzymology; Liver - ultrastructure; Male; Microbodies - enzymology; Microbodies - ultrastructure; Microscopy, Fluorescence; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley; Transferases; Transferases - metabolism; Zellweger Syndrome - enzymology; Human; Rat; Enzyme; Transferases; Liver; Rodentia; Geranyltranstransferase; Vertebrata; Mammalia; Peroxisome; Immunoelectron microscopy; Immunofluorescence; Localization

In this study, we have investigated the subcellular localization of farnesyl-diphosphate synthase (FPP synthase). FPP synthase produces FPP, which is utilized in the synthesis of squalene, cholesterol, farnesylated and geranylgeranylated proteins, dolichols, coenzyme Q, and the isoprenoid moiety of...