Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT + Endothelial Progenitor Cells

• Published in: American journal of respiratory and critical care medicine Vol. 200; no. 9; pp. 1164 - 1176
• Main Authors: Ren, Xiaomeng, Ustiyan, Vladimir, Guo, Minzhe, Wang, Guolun, Bolte, Craig, Zhang, Yufang, Xu, Yan, Whitsett, Jeffrey A, Kalin, Tanya V, Kalinichenko, Vladimir V
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2019
• Subjects: Angiogenesis; Animals; Apoptosis; Endothelial Progenitor Cells - physiology; Forkhead Transcription Factors - physiology; Humans; Hyperoxia; Infant, Newborn; Lung - growth & development; Lung diseases; Mice; Original; Pediatrics; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Proto-Oncogene Proteins c-kit - metabolism; Signal Transduction - physiology; Tissue Culture Techniques; C-KIT; bronchopulmonary dysplasia; FOXF1; endothelial progenitor cells

Disruption of alveologenesis is associated with severe pediatric lung disorders, including bronchopulmonary dysplasia (BPD). Although c-KIT endothelial cell (EC) progenitors are abundant in embryonic and neonatal lungs, their role in alveolar septation and the therapeutic potential of these cells re...