Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid

• Published in: Cancer discovery Vol. 13; no. 8; pp. 1884 - 1903
• Main Authors: Frank, Anderson R, Li, Vicky, Shelton, Spencer D, Kim, Jiwoong, Stott, Gordon M, Neckers, Leonard M, Xie, Yang, Williams, Noelle S, Mishra, Prashant, McFadden, David G
• Format: Journal Article
• Language: English
• Published: United States 04.08.2023
• Subjects: Adenocarcinoma; Adenoma, Oxyphilic - genetics; Carcinoma; DNA, Mitochondrial - genetics; Fermentation; Humans; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology

A metabolic hallmark of cancer identified by Warburg is the increased consumption of glucose and secretion of lactate, even in the presence of oxygen. Although many tumors exhibit increased glycolytic activity, most forms of cancer rely on mitochondrial respiration for tumor growth. We report here t...