The Serum Concentrations of Hedgehog-Interacting Protein, a Novel Biomarker, Were Decreased in Overweight or Obese Subjects

• Published in: Journal of clinical medicine Vol. 10; no. 4; p. 742
• Main Authors: Chou, Hsuan-Wen, Hung, Hao-Chang, Lin, Ching-Han, Lin, An-Chi, Du, Ye-Fong, Cheng, Kai-Pi, Li, Chung-Hao, Chang, Chih-Jen, Wu, Hung-Tsung, Ou, Horng-Yih
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.02.2021; MDPI
• Subjects: Adipocytes; Blood pressure; Body mass index; Cholesterol; Clinical medicine; Diabetes; Glucose; High density lipoprotein; Homeostasis; Insulin resistance; Laboratories; Lipoproteins; Obesity; Overweight; Proteins; Regression analysis; Triglycerides; Variance analysis; United States > US; Japan; Taiwan; hedgehog-interacting protein; impaired glucose tolerance; normal glucose tolerance; impaired fasting glucose; newly diagnosed diabetes

Although it was known that obesity is an independent risk factor for metabolic disorders including diabetes, the factors that link these diseases were obscure. The Hedgehog-interacting protein (Hhip) is a negative regulator in tissue remodeling, and inhibits the proliferation of adipocytes, and prom...