Recent advances in the total synthesis of cyclobutane-containing natural products

Complex natural products bearing strained cyclobutane subunits, including terpenoids, alkaloids and steroids, not only display fascinating architectures, but also show potent biological activities. Due to their unique structures as critical core skeletons in these molecules, a variety of new strateg...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 7; no. 1; pp. 136 - 154
Main Authors Li, Jinshan, Gao, Kai, Bian, Ming, Ding, Hanfeng
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 01.01.2020
Subjects
Alkaloids
Cyclobutane
Natural products
Organic chemistry
Steroid hormones
Steroids
Synthesis
Tactics
Terpenes
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Summary:Complex natural products bearing strained cyclobutane subunits, including terpenoids, alkaloids and steroids, not only display fascinating architectures, but also show potent biological activities. Due to their unique structures as critical core skeletons in these molecules, a variety of new strategies for the construction of cyclobutane rings have greatly emerged during the last decade. In this review, we wish to summarize the recent progress in the cyclobutane-containing natural product synthesis with an emphasis on disconnection tactics employed to forge the four-membered rings, aiming to provide a complement to existing reviews.
ISSN:2052-4110
2052-4110
DOI:10.1039/c9qo01178a