Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes
Methylglyoxal (MG) may be an important cause of diabetic complications. Its primary source is dihydroxyacetone phosphate (DHAP) whose levels are partially controlled by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Using a human red blood cell (RBC) culture, we examined the effect of modifying G...
Saved in:
Published in | Biochimica et biophysica acta Vol. 1637; no. 1; pp. 98 - 106 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
20.01.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Methylglyoxal (MG) may be an important cause of diabetic complications. Its primary source is dihydroxyacetone phosphate (DHAP) whose levels are partially controlled by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Using a human red blood cell (RBC) culture, we examined the effect of modifying GAPDH activity on MG production. With the inhibitor koningic acid (KA), we showed a linear, concentration-dependent GAPDH inhibition, with 5 μM KA leading to a 79% reduction of GAPDH activity and a sixfold increase in MG. Changes in redox state produced by elevated pH also resulted in a 2.4-fold increase in MG production at pH 7.5 and a 13.4-fold increase at pH 7.8. We found substantial inter-individual variation in DHAP and MG levels and an inverse relationship between GAPDH activity and MG production (
R=0.57,
P=0.005) in type 2 diabetes. A similar relationship between GAPDH activity and MG was observed in vivo in type 1 diabetes (
R=0.29,
P=0.0018).
Widely varying rates of progression of diabetic complications are seen among individuals. We postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for this observation. |
---|---|
AbstractList | Methylglyoxal (MG) may be an important cause of diabetic complications. Its primary source is dihydroxyacetone phosphate (DHAP) whose levels are partially controlled by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Using a human red blood cell (RBC) culture, we examined the effect of modifying GAPDH activity on MG production. With the inhibitor koningic acid (KA), we showed a linear, concentration-dependent GAPDH inhibition, with 5 microM KA leading to a 79% reduction of GAPDH activity and a sixfold increase in MG. Changes in redox state produced by elevated pH also resulted in a 2.4-fold increase in MG production at pH 7.5 and a 13.4-fold increase at pH 7.8. We found substantial inter-individual variation in DHAP and MG levels and an inverse relationship between GAPDH activity and MG production (R=0.57, P=0.005) in type 2 diabetes. A similar relationship between GAPDH activity and MG was observed in vivo in type 1 diabetes (R=0.29, P=0.0018). Widely varying rates of progression of diabetic complications are seen among individuals. We postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for this observation. Methylglyoxal (MG) may be an important cause of diabetic complications. Its primary source is dihydroxyacetone phosphate (DHAP) whose levels are partially controlled by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Using a human red blood cell (RBC) culture, we examined the effect of modifying GAPDH activity on MG production. With the inhibitor koningic acid (KA), we showed a linear, concentration-dependent GAPDH inhibition, with 5 μM KA leading to a 79% reduction of GAPDH activity and a sixfold increase in MG. Changes in redox state produced by elevated pH also resulted in a 2.4-fold increase in MG production at pH 7.5 and a 13.4-fold increase at pH 7.8. We found substantial inter-individual variation in DHAP and MG levels and an inverse relationship between GAPDH activity and MG production ( R=0.57, P=0.005) in type 2 diabetes. A similar relationship between GAPDH activity and MG was observed in vivo in type 1 diabetes ( R=0.29, P=0.0018). Widely varying rates of progression of diabetic complications are seen among individuals. We postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for this observation. |
Author | Szwergold, Benjamin S Beisswenger, Paul J Smith, Kenneth Howell, Scott K |
Author_xml | – sequence: 1 givenname: Paul J surname: Beisswenger fullname: Beisswenger, Paul J email: paul.j.beisswenger@hitchcock.org – sequence: 2 givenname: Scott K surname: Howell fullname: Howell, Scott K – sequence: 3 givenname: Kenneth surname: Smith fullname: Smith, Kenneth – sequence: 4 givenname: Benjamin S surname: Szwergold fullname: Szwergold, Benjamin S |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12527413$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1r3DAQhkVISTZp_kEoOpX24EZf_tClUEKbFgI5JIHehCyNsiqy5Ujapf738WaX5tY5zMDwvDPwnKHjMY6A0CUlXyihzdU9kawWgstPhH0mhFFZ8SO0ol0rK9aQ38dotSOqHXKKznL-Q5ZqWnKCTimrWSsoX6HpJswGkg4W1rOFilfTOuZprQvg11WKTzDqDFib4re-zFhnrEfsRwsTLG0seIjWOw8JR4cHKOs5PIU5_tUBB9hCyAuMrdc9FMjv0TunQ4aLwzxHjz--P1z_rG7vbn5df7utjCCyVNrKxjUG6lpw1lnBHDPQNJJr17FeCweto502sqekqWsnueu1bElHai4NdfwcfdzfnVJ83kAuavDZQAh6hLjJqmWyFoyzBRR70KSYcwKnpuQHnWZFidqZVv9MK8LUq2nFl9iHw_1NP4B9Cx3ULsDXPbAIgO1iR2XjYTRgfQJTlI3-_x9eAH9RkV4 |
CitedBy_id | crossref_primary_10_1074_jbc_M403070200 crossref_primary_10_1016_j_arr_2009_09_004 crossref_primary_10_1152_ajpendo_00317_2009 crossref_primary_10_1155_2007_43603 crossref_primary_10_1007_s10528_024_10881_8 crossref_primary_10_1007_s12291_015_0486_0 crossref_primary_10_1016_j_vph_2012_03_005 crossref_primary_10_1074_jbc_M513813200 crossref_primary_10_3390_antiox12030771 crossref_primary_10_1016_j_bcp_2010_04_037 crossref_primary_10_1038_s41598_018_19425_8 crossref_primary_10_1007_s40502_016_0260_1 crossref_primary_10_1016_j_abb_2022_109485 crossref_primary_10_1111_j_1750_3841_2009_01166_x crossref_primary_10_1016_j_redox_2020_101799 crossref_primary_10_1196_annals_1333_017 crossref_primary_10_1016_j_redox_2013_09_005 crossref_primary_10_1002_bmc_2803 crossref_primary_10_1016_S1262_3636_03_72793_1 crossref_primary_10_1016_j_trsl_2011_12_004 crossref_primary_10_1089_ars_2007_1630 crossref_primary_10_2217_epi_2016_0002 crossref_primary_10_1016_j_abb_2020_108744 crossref_primary_10_1139_y06_080 crossref_primary_10_14336_AD_2016_1030 crossref_primary_10_1007_s00125_012_2452_1 crossref_primary_10_1016_j_brainres_2004_01_066 crossref_primary_10_1017_S0029665108006034 crossref_primary_10_12677_ACM_2020_103050 crossref_primary_10_1016_j_exer_2023_109650 crossref_primary_10_1038_s41538_021_00105_3 crossref_primary_10_1155_2018_3420187 crossref_primary_10_17116_jnevro201611691116_125 crossref_primary_10_1155_2018_4321714 crossref_primary_10_3390_metabo10100413 crossref_primary_10_1152_physrev_00001_2019 crossref_primary_10_1016_j_diabres_2012_11_003 crossref_primary_10_1152_ajpendo_00186_2013 crossref_primary_10_1155_2014_131607 crossref_primary_10_1016_j_diabres_2013_03_031 crossref_primary_10_1111_j_1442_9071_2011_02695_x crossref_primary_10_1016_j_stemcr_2020_08_002 crossref_primary_10_2337_diabetes_54_11_3274 crossref_primary_10_1002_jcp_25310 crossref_primary_10_1016_j_abb_2024_110065 crossref_primary_10_1289_ehp_8786 crossref_primary_10_3389_fnut_2022_1037186 crossref_primary_10_1007_s10863_014_9551_2 crossref_primary_10_1016_j_ejmech_2020_112740 crossref_primary_10_1093_toxsci_kfi158 crossref_primary_10_1002_mds_26566 crossref_primary_10_1177_1535370217703353 crossref_primary_10_1016_j_freeradbiomed_2021_01_041 crossref_primary_10_1007_s12013_007_0039_0 crossref_primary_10_1007_s11033_016_3947_5 crossref_primary_10_1021_acs_jnatprod_0c01155 crossref_primary_10_3390_molecules27031111 crossref_primary_10_3390_antiox11051005 crossref_primary_10_1179_135100008X309046 crossref_primary_10_1080_13813450701384783 crossref_primary_10_2147_vhrm_2006_2_3_263 crossref_primary_10_3390_antiox10020253 crossref_primary_10_3389_fviro_2021_682136 crossref_primary_10_3390_antiox11102003 crossref_primary_10_1111_j_1471_4159_2010_06693_x crossref_primary_10_3389_fpls_2018_00667 crossref_primary_10_3389_fnins_2022_970925 crossref_primary_10_1016_j_fct_2022_112982 crossref_primary_10_1002_mnfr_200600065 crossref_primary_10_1007_s12010_020_03313_x crossref_primary_10_1021_acs_chemrestox_5b00171 crossref_primary_10_1080_14756360802187679 crossref_primary_10_1155_2020_8819719 crossref_primary_10_1111_jfbc_13688 crossref_primary_10_1134_S0006297915130039 crossref_primary_10_1186_s40942_016_0033_z crossref_primary_10_1134_S0006297917080028 crossref_primary_10_1196_annals_1333_025 crossref_primary_10_1210_clinem_dgab362 crossref_primary_10_1016_j_bbrc_2004_06_011 crossref_primary_10_1016_j_cca_2021_06_002 crossref_primary_10_1271_bbb_130353 crossref_primary_10_1007_s00547_005_2033_y crossref_primary_10_1002_wsbm_1486 crossref_primary_10_1016_j_dsx_2020_08_037 crossref_primary_10_1016_j_chroma_2005_10_063 |
Cites_doi | 10.1074/jbc.271.32.19338 10.1016/0167-4838(88)90086-6 10.1152/ajpcell.2001.280.4.C867 10.1016/0145-2126(95)00162-X 10.1074/jbc.M100385200 10.1002/cbf.290070111 10.1016/S0925-4439(97)00084-7 10.1016/S0021-9258(19)37593-3 10.1038/35008121 10.1016/0304-3940(94)90214-3 10.1016/S0076-6879(82)89059-9 10.1016/S0006-2952(99)00132-X 10.1007/s001250051090 10.1111/j.1749-6632.2001.tb05634.x 10.2337/diab.42.6.801 10.1016/S0021-9258(19)77928-9 10.1016/0006-291X(80)91596-X 10.1016/S0021-9258(18)41847-9 10.1111/j.1432-1033.1993.tb17638.x 10.1016/0304-4165(84)90166-1 10.1055/s-2007-1018980 10.1007/BF01871953 10.1016/0167-4838(92)90431-C 10.1056/NEJM199309303291401 10.1042/bj3090133 10.1002/ijc.2910540315 10.1016/S0021-9258(17)33239-8 10.7164/antibiotics.38.920 10.1126/science.3487117 10.1093/oxfordjournals.jbchem.a021749 10.1242/jcs.114.9.1643 10.1016/S1357-2725(01)00010-3 10.1016/0378-4347(87)80033-6 10.1016/S0026-0495(98)90026-9 10.1074/jbc.273.1.446 10.1271/bbb1961.50.1959 10.1016/S0003-2697(05)80005-3 10.1006/abbi.2001.2691 10.1093/hmg/5.9.1311 10.1152/ajpcell.1998.275.1.C75 10.2337/diab.40.10.1328 10.1006/bbrc.1998.8806 10.1016/0006-2952(94)90584-3 10.2337/diab.43.6.836 10.1002/(SICI)1097-4644(19970801)66:2<133::AID-JCB1>3.0.CO;2-R 10.1016/S0024-3205(98)00336-1 10.1042/bst0210549 10.1038/nm0396-347 10.1172/JCI116482 10.1023/A:1006831511527 10.2337/diabetes.48.1.198 10.1016/0925-4439(94)90022-1 10.1111/j.1432-1033.1975.tb09823.x 10.1038/350121a0 10.1046/j.1471-4159.1997.68062493.x 10.1016/S0378-4347(00)83093-5 10.1016/S0006-8993(00)02047-3 10.1046/j.1471-4159.2001.00033.x 10.1042/bj2500625 10.1111/j.1432-1033.1994.tb18821.x 10.1016/S0167-4838(99)00119-3 10.1016/0306-3623(95)02054-3 10.1016/S0014-2999(99)00342-8 10.2337/diabetes.51.5.1580 10.1016/S0021-9258(18)53264-6 10.1016/S0021-9258(17)40462-5 |
ContentType | Journal Article |
Copyright | 2002 Elsevier Science B.V. |
Copyright_xml | – notice: 2002 Elsevier Science B.V. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/S09254439(02)00219-3 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry Biology |
EISSN | 1879-260X |
EndPage | 106 |
ExternalDocumentID | 10_1016_S09254439_02_00219_3 12527413 S0925443902002193 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6I. 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABEFU ABFNM ABGSF ABLVK ABMAC ABMZM ABUDA ABVKL ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AEXQZ AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE IXB J1W KOM LCYCR LX3 M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SDF SDG SDP SES SEW SPCBC SSH SSU SSZ T5K UQL WUQ XJT XPP ~G- -~X .55 .GJ ABJNI AKRWK CGR CUY CVF ECM EIF F5P H~9 NPM RIG TWZ WH7 X7M Y6R ZGI ~KM 0SF AAXKI AAYXX ADVLN AFJKZ CITATION 7X8 |
ID | FETCH-LOGICAL-c409t-ad96f6ce554328d42f2ce6693af82ba4fe7f18ac9b10655f93fba97080539c1f3 |
IEDL.DBID | IXB |
ISSN | 0925-4439 0006-3002 |
IngestDate | Fri Aug 16 12:19:04 EDT 2024 Thu Sep 26 18:49:27 EDT 2024 Sat Sep 28 08:38:58 EDT 2024 Fri Feb 23 02:30:36 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | Red blood cell Methylglyoxal Glyceraldehyde-3-phosphate dehydrogenase Carbohydrate metabolism Diabetes |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c409t-ad96f6ce554328d42f2ce6693af82ba4fe7f18ac9b10655f93fba97080539c1f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0925443902002193 |
PMID | 12527413 |
PQID | 72954232 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_72954232 crossref_primary_10_1016_S09254439_02_00219_3 pubmed_primary_12527413 elsevier_sciencedirect_doi_10_1016_S09254439_02_00219_3 |
PublicationCentury | 2000 |
PublicationDate | 2003-01-20 |
PublicationDateYYYYMMDD | 2003-01-20 |
PublicationDate_xml | – month: 01 year: 2003 text: 2003-01-20 day: 20 |
PublicationDecade | 2000 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Biochimica et biophysica acta |
PublicationTitleAlternate | Biochim Biophys Acta |
PublicationYear | 2003 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | Golej, Hoeger, Radner, Unfried, Lubec (BIB7) 1998; 63 Tanaka, Uchino, Shimizu, Yoshii, Niwa, Ohmura, Mitsuhashi, Onuma, Kawamori (BIB69) 1999; 376 Hartman, Norton (BIB55) 1976; 251 Dumaswala, Zhuo, Mahajan, Nair, Shertzer, Dibello, Jacobsen (BIB65) 2001; 280 Bird, Nunn, Lord (BIB15) 1984; 802 Knowles (BIB13) 1991; 350 Scionti, Puxeddu, Calabrese, Gatteschi, De Angelis, Bolli, Compagnucci, Calafiore, Brunetti (BIB62) 1982; 14 Beutler, Duron, Kelly (BIB41) 1963 (May) Beisswenger, Smith, Howell, Touchette, Szwergold (BIB52) 1998; 47 Kang, Edwards, Thornalley (BIB4) 1996; 20 Endo, Hasumi, Sakai, Kanbe (BIB53) 1985; 38 Ercolani, Florence, Denaro, Alexander (BIB25) 1988; 263 Hayashi, Mase, Namiki (BIB14) 1986; 50 Kato, Sakai, Endo (BIB49) 1992; 1120 Hyslop, Hinshaw, Halsey, Schraufstatter, Sauerheber, Spragg, Jackson, Cochrane (BIB37) 1988; 263 Beisswenger, Lal, Howell, Stevens, Siegel, Yeo, Randall, Brown, Szwergold (BIB51) 1998 Tilton, Seaman, Carriero, Piomelli (BIB16) 1991; 118 Sirover (BIB18) 1999; 1432 He, Yang, Zheng, Zhou (BIB35) 1995; 309 Mazzola, Sirover (BIB24) 2001; 76 Milhausen, Levy (BIB54) 1975; 50 Stevens, Vlassara, Abati, Cerami (BIB58) 1977; 252 Byers (BIB42) 1982; 89 Pt D Kim, Kwon, Yoon, Lee, Rhee (BIB23) 2002; 397 (BIB56) 1993; 329 Gonzalez, Sochor, McLean (BIB60) 1980; 95 Ohmori, Mori, Kawase, Tsuboi (BIB44) 1987; 414 Amicarelli, Colafarina, Cesare, Aimola, Di Ilio, Miranda, Ragnelli (BIB6) 2001; 33 Godbout, Pesavento, Hartman, Manson, Freund (BIB68) 2002; 277 Uchida, Stadtman (BIB29) 1993; 268 Beisswenger, Howell, Touchette, Lal, Szwergold (BIB10) 1999; 48 Aki, Yanagisawa, Akanuma (BIB39) 1997; 122 Shinpo, Kikuchi, Sasaki, Ogata, Moriwaka, Tashiro (BIB3) 2000; 861 Nagaraj, Shipanova, Faust (BIB50) 1996; 271 Yim, Yim, Lee, Kang, Chock (BIB5) 2001; 928 Soulis-Liparata, Cooper, Papazoglou, Jerums (BIB8) 1991; 40 Halder, Ray, Ray (BIB33) 1993; 54 Hook, Harding (BIB36) 1997; 1362 Nishikawa, Edelstein, Du, Yamagishi, Matsumura, Kaneda, Yorek, Beebe, Oates, Hammes, Giardino, Brownlee (BIB64) 2000; 404 Lo, Selwood, Thornalley (BIB71) 1994; 48 Michal, Beutler (BIB43) 1974; vol. 3 Brownlee, Vlassara, Kooney, Ulrich, Cerami (BIB9) 1986; 232 Brownlee (BIB1) 1994; 43 Leyva, Wingrove, Godsland, Stevenson (BIB72) 1998; 47 Ohmori, Iwamoto (BIB46) 1988; 431 Taylor, Agius (BIB66) 1988; 250 Hipkiss, Chana (BIB70) 1998; 248 Koshy, Matilla, Burright, Merry, Fischbeck, Orr, Zoghbi (BIB21) 1996; 5 Trueblood, Ramasamy (BIB57) 1998; 275 McLellan, Phillips, Thornalley (BIB45) 1992; 206 Ray, Basu, Ray (BIB34) 1997; 177 Richard (BIB12) 1993; 21 Seipp, Buselmaier (BIB19) 1994; 182 Sirover (BIB17) 1997; 66 Nakazawa, Uehara, Nomura (BIB28) 1997; 68 Drummond, Mauer (BIB48) 2002; 51 Schuppe-Koistinen, Moldeus, Bergman, Cotgreave (BIB27) 1994; 221 Dastoor, Dreyer (BIB22) 2001; 114 Burke, Enghild, Martin, Jou, Myers, Roses, Vance, Strittmatter (BIB20) 1996; 2 Novotny, Yancey, Stuart, Wiesler, Peterson (BIB31) 1994; 1226 Thornalley (BIB2) 1996; 27 Shinohara, Loros, Dunlap (BIB40) 1998; 273 Dimmeler, Lottspeich, Brune (BIB30) 1992; 267 Leoncini, Maresca, Buzzi (BIB32) 1989; 7 Phillips, Thornalley (BIB11) 1993; 212 Freedman (BIB47) 1983; 75 Ryzlak, Pietruszko (BIB26) 1988; 954 Tegos, Beutler (BIB61) 1980; 96 Williamson, Chang, Frangos, Hasan, Ido, Kawamura, Nyengaard, van den Enden, Kilo, Tilton (BIB38) 1993; 42 McCance, Dyer, Dunn, Bailie, Thorpe, Baynes, Lyons (BIB63) 1993; 91 Abordo, Minhas, Thornalley (BIB67) 1999; 58 Obrosova, Cao, Greene, Stevens (BIB59) 1998; 41 Bird (10.1016/S09254439(02)00219-3_BIB15) 1984; 802 Kim (10.1016/S09254439(02)00219-3_BIB23) 2002; 397 Dastoor (10.1016/S09254439(02)00219-3_BIB22) 2001; 114 He (10.1016/S09254439(02)00219-3_BIB35) 1995; 309 Beisswenger (10.1016/S09254439(02)00219-3_BIB52) 1998; 47 Sirover (10.1016/S09254439(02)00219-3_BIB18) 1999; 1432 Beisswenger (10.1016/S09254439(02)00219-3_BIB10) 1999; 48 Hipkiss (10.1016/S09254439(02)00219-3_BIB70) 1998; 248 McCance (10.1016/S09254439(02)00219-3_BIB63) 1993; 91 Milhausen (10.1016/S09254439(02)00219-3_BIB54) 1975; 50 Taylor (10.1016/S09254439(02)00219-3_BIB66) 1988; 250 Golej (10.1016/S09254439(02)00219-3_BIB7) 1998; 63 Soulis-Liparata (10.1016/S09254439(02)00219-3_BIB8) 1991; 40 Kato (10.1016/S09254439(02)00219-3_BIB49) 1992; 1120 Freedman (10.1016/S09254439(02)00219-3_BIB47) 1983; 75 Leoncini (10.1016/S09254439(02)00219-3_BIB32) 1989; 7 Drummond (10.1016/S09254439(02)00219-3_BIB48) 2002; 51 (10.1016/S09254439(02)00219-3_BIB56) 1993; 329 Tegos (10.1016/S09254439(02)00219-3_BIB61) 1980; 96 Burke (10.1016/S09254439(02)00219-3_BIB20) 1996; 2 Gonzalez (10.1016/S09254439(02)00219-3_BIB60) 1980; 95 Koshy (10.1016/S09254439(02)00219-3_BIB21) 1996; 5 Ryzlak (10.1016/S09254439(02)00219-3_BIB26) 1988; 954 Uchida (10.1016/S09254439(02)00219-3_BIB29) 1993; 268 Trueblood (10.1016/S09254439(02)00219-3_BIB57) 1998; 275 Ercolani (10.1016/S09254439(02)00219-3_BIB25) 1988; 263 Tilton (10.1016/S09254439(02)00219-3_BIB16) 1991; 118 Godbout (10.1016/S09254439(02)00219-3_BIB68) 2002; 277 Ohmori (10.1016/S09254439(02)00219-3_BIB46) 1988; 431 Beisswenger (10.1016/S09254439(02)00219-3_BIB51) 1998 Leyva (10.1016/S09254439(02)00219-3_BIB72) 1998; 47 Aki (10.1016/S09254439(02)00219-3_BIB39) 1997; 122 Thornalley (10.1016/S09254439(02)00219-3_BIB2) 1996; 27 Dumaswala (10.1016/S09254439(02)00219-3_BIB65) 2001; 280 Endo (10.1016/S09254439(02)00219-3_BIB53) 1985; 38 Kang (10.1016/S09254439(02)00219-3_BIB4) 1996; 20 Williamson (10.1016/S09254439(02)00219-3_BIB38) 1993; 42 McLellan (10.1016/S09254439(02)00219-3_BIB45) 1992; 206 Hyslop (10.1016/S09254439(02)00219-3_BIB37) 1988; 263 Obrosova (10.1016/S09254439(02)00219-3_BIB59) 1998; 41 Hartman (10.1016/S09254439(02)00219-3_BIB55) 1976; 251 Knowles (10.1016/S09254439(02)00219-3_BIB13) 1991; 350 Seipp (10.1016/S09254439(02)00219-3_BIB19) 1994; 182 Shinpo (10.1016/S09254439(02)00219-3_BIB3) 2000; 861 Brownlee (10.1016/S09254439(02)00219-3_BIB9) 1986; 232 Tanaka (10.1016/S09254439(02)00219-3_BIB69) 1999; 376 Lo (10.1016/S09254439(02)00219-3_BIB71) 1994; 48 Beutler (10.1016/S09254439(02)00219-3_BIB41) 1963 Amicarelli (10.1016/S09254439(02)00219-3_BIB6) 2001; 33 Novotny (10.1016/S09254439(02)00219-3_BIB31) 1994; 1226 Ohmori (10.1016/S09254439(02)00219-3_BIB44) 1987; 414 Phillips (10.1016/S09254439(02)00219-3_BIB11) 1993; 212 Schuppe-Koistinen (10.1016/S09254439(02)00219-3_BIB27) 1994; 221 Shinohara (10.1016/S09254439(02)00219-3_BIB40) 1998; 273 Hayashi (10.1016/S09254439(02)00219-3_BIB14) 1986; 50 Brownlee (10.1016/S09254439(02)00219-3_BIB1) 1994; 43 Mazzola (10.1016/S09254439(02)00219-3_BIB24) 2001; 76 Richard (10.1016/S09254439(02)00219-3_BIB12) 1993; 21 Nishikawa (10.1016/S09254439(02)00219-3_BIB64) 2000; 404 Scionti (10.1016/S09254439(02)00219-3_BIB62) 1982; 14 Yim (10.1016/S09254439(02)00219-3_BIB5) 2001; 928 Sirover (10.1016/S09254439(02)00219-3_BIB17) 1997; 66 Abordo (10.1016/S09254439(02)00219-3_BIB67) 1999; 58 Michal (10.1016/S09254439(02)00219-3_BIB43) 1974; vol. 3 Dimmeler (10.1016/S09254439(02)00219-3_BIB30) 1992; 267 Ray (10.1016/S09254439(02)00219-3_BIB34) 1997; 177 Stevens (10.1016/S09254439(02)00219-3_BIB58) 1977; 252 Nagaraj (10.1016/S09254439(02)00219-3_BIB50) 1996; 271 Nakazawa (10.1016/S09254439(02)00219-3_BIB28) 1997; 68 Hook (10.1016/S09254439(02)00219-3_BIB36) 1997; 1362 Halder (10.1016/S09254439(02)00219-3_BIB33) 1993; 54 Byers (10.1016/S09254439(02)00219-3_BIB42) 1982; 89 Pt D |
References_xml | – volume: 277 start-page: 2554 year: 2002 end-page: 2561 ident: BIB68 publication-title: Journal of Biological Chemistry contributor: fullname: Freund – volume: 41 start-page: 1442 year: 1998 end-page: 1450 ident: BIB59 publication-title: Diabetologia contributor: fullname: Stevens – volume: 96 start-page: 85 year: 1980 end-page: 89 ident: BIB61 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Beutler – volume: 861 start-page: 151 year: 2000 end-page: 159 ident: BIB3 publication-title: Brain Research contributor: fullname: Tashiro – volume: 268 start-page: 6388 year: 1993 end-page: 6393 ident: BIB29 publication-title: Journal of Biological Chemistry contributor: fullname: Stadtman – volume: 404 start-page: 787 year: 2000 end-page: 790 ident: BIB64 publication-title: Nature contributor: fullname: Brownlee – volume: 33 start-page: 1129 year: 2001 end-page: 1139 ident: BIB6 publication-title: International Journal of Biochemistry and Cell Biology contributor: fullname: Ragnelli – volume: 414 start-page: 149 year: 1987 end-page: 155 ident: BIB44 publication-title: Journal of Chromatography contributor: fullname: Tsuboi – volume: 177 start-page: 21 year: 1997 end-page: 26 ident: BIB34 publication-title: Molecular and Cellular Biochemistry contributor: fullname: Ray – volume: 928 start-page: 48 year: 2001 end-page: 53 ident: BIB5 publication-title: Annals of the New York Academy of Sciences contributor: fullname: Chock – volume: 376 start-page: 17 year: 1999 end-page: 22 ident: BIB69 publication-title: European Journal of Pharmacology contributor: fullname: Kawamori – volume: 263 start-page: 1665 year: 1988 end-page: 1675 ident: BIB37 publication-title: Journal of Biological Chemistry contributor: fullname: Cochrane – volume: 273 start-page: 446 year: 1998 end-page: 452 ident: BIB40 publication-title: Journal of Biological Chemistry contributor: fullname: Dunlap – volume: 267 start-page: 16771 year: 1992 end-page: 16774 ident: BIB30 publication-title: Journal of Biological Chemistry contributor: fullname: Brune – volume: 47 start-page: 657 year: 1998 end-page: 662 ident: BIB72 publication-title: Metabolism, Clinical and Experimental contributor: fullname: Stevenson – volume: 50 start-page: 1959 year: 1986 end-page: 1964 ident: BIB14 publication-title: Agricultural and Biological Chemistry contributor: fullname: Namiki – volume: 27 start-page: 565 year: 1996 end-page: 573 ident: BIB2 publication-title: General Pharmacology contributor: fullname: Thornalley – volume: 42 start-page: 801 year: 1993 end-page: 813 ident: BIB38 publication-title: Diabetes contributor: fullname: Tilton – volume: 206 start-page: 17 year: 1992 end-page: 23 ident: BIB45 publication-title: Analytical Biochemistry contributor: fullname: Thornalley – volume: 14 start-page: 233 year: 1982 end-page: 236 ident: BIB62 publication-title: Hormone and Metabolic Research contributor: fullname: Brunetti – volume: 263 start-page: 15335 year: 1988 end-page: 15341 ident: BIB25 publication-title: Journal of Biological Chemistry contributor: fullname: Alexander – volume: 7 start-page: 65 year: 1989 end-page: 70 ident: BIB32 publication-title: Cell Biochemistry and Function contributor: fullname: Buzzi – volume: 1432 start-page: 159 year: 1999 end-page: 184 ident: BIB18 publication-title: Biochimica et Biophysica Acta contributor: fullname: Sirover – volume: 954 start-page: 309 year: 1988 end-page: 324 ident: BIB26 publication-title: Biochimica et Biophysica Acta contributor: fullname: Pietruszko – volume: 252 start-page: 2998 year: 1977 end-page: 3002 ident: BIB58 publication-title: Journal of Biological Chemistry contributor: fullname: Cerami – volume: 118 start-page: 146 year: 1991 end-page: 152 ident: BIB16 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Piomelli – volume: 280 start-page: C867 year: 2001 end-page: C873 ident: BIB65 publication-title: American Journal of Physiology. Cell Physiology contributor: fullname: Jacobsen – volume: 248 start-page: 28 year: 1998 end-page: 32 ident: BIB70 publication-title: Biochemical and Biophysical Research Communications contributor: fullname: Chana – volume: 431 start-page: 239 year: 1988 end-page: 247 ident: BIB46 publication-title: Journal of Chromatography contributor: fullname: Iwamoto – volume: 309 start-page: 133 year: 1995 end-page: 139 ident: BIB35 publication-title: Biochemical Journal contributor: fullname: Zhou – volume: 66 start-page: 133 year: 1997 end-page: 140 ident: BIB17 publication-title: Journal of Cellular Biochemistry contributor: fullname: Sirover – volume: 75 start-page: 225 year: 1983 end-page: 231 ident: BIB47 publication-title: Journal of Membrane Biology contributor: fullname: Freedman – volume: 20 start-page: 397 year: 1996 end-page: 405 ident: BIB4 publication-title: Leukemia Research contributor: fullname: Thornalley – volume: 51 start-page: 1572 year: 2002 end-page: 1579 ident: BIB48 publication-title: Diabetes contributor: fullname: Mauer – volume: 221 start-page: 1033 year: 1994 end-page: 1037 ident: BIB27 publication-title: European Journal of Biochemistry contributor: fullname: Cotgreave – volume: 329 start-page: 977 year: 1993 end-page: 986 ident: BIB56 publication-title: New England Journal of Medicine – start-page: 882 year: 1963 (May) end-page: 888 ident: BIB41 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Kelly – volume: 275 start-page: H75 year: 1998 end-page: H83 ident: BIB57 publication-title: American Journal of Physiology contributor: fullname: Ramasamy – volume: 2 year: 1996 ident: BIB20 publication-title: Nature Medicine contributor: fullname: Strittmatter – volume: 91 start-page: 2470 year: 1993 end-page: 2478 ident: BIB63 publication-title: Journal of Clinical Investigation contributor: fullname: Lyons – volume: 47 start-page: A80 year: 1998 ident: BIB52 publication-title: Diabetes contributor: fullname: Szwergold – volume: 63 start-page: 801 year: 1998 end-page: 807 ident: BIB7 publication-title: Life Sciences contributor: fullname: Lubec – volume: 50 start-page: 453 year: 1975 end-page: 461 ident: BIB54 publication-title: European Journal of Biochemistry contributor: fullname: Levy – volume: 58 start-page: 641 year: 1999 end-page: 648 ident: BIB67 publication-title: Biochemical Pharmacology contributor: fullname: Thornalley – volume: 182 start-page: 91 year: 1994 end-page: 94 ident: BIB19 publication-title: Neuroscience Letters contributor: fullname: Buselmaier – volume: 68 start-page: 2493 year: 1997 end-page: 2499 ident: BIB28 publication-title: Journal of Neurochemistry contributor: fullname: Nomura – volume: 802 start-page: 229 year: 1984 end-page: 236 ident: BIB15 publication-title: Biochimica et Biophysica Acta contributor: fullname: Lord – volume: 5 start-page: 1311 year: 1996 end-page: 1318 ident: BIB21 publication-title: Human Molecular Genetics contributor: fullname: Zoghbi – volume: 1120 start-page: 113 year: 1992 end-page: 116 ident: BIB49 publication-title: Biochimica et Biophysica Acta contributor: fullname: Endo – volume: 21 start-page: 549 year: 1993 end-page: 553 ident: BIB12 publication-title: Biochemical Society Transactions contributor: fullname: Richard – volume: 397 start-page: 414 year: 2002 end-page: 423 ident: BIB23 publication-title: Archives of Biochemistry and Biophysics contributor: fullname: Rhee – volume: 76 start-page: 442 year: 2001 end-page: 449 ident: BIB24 publication-title: Journal of Neurochemistry contributor: fullname: Sirover – volume: 271 start-page: 19338 year: 1996 end-page: 19345 ident: BIB50 publication-title: Journal of Biological Chemistry contributor: fullname: Faust – volume: 250 start-page: 625 year: 1988 end-page: 640 ident: BIB66 publication-title: Biochemical Journal contributor: fullname: Agius – volume: 232 start-page: 1629 year: 1986 end-page: 1632 ident: BIB9 publication-title: Science contributor: fullname: Cerami – volume: 89 Pt D start-page: 326 year: 1982 end-page: 335 ident: BIB42 publication-title: Methods in Enzymology contributor: fullname: Byers – volume: 38 start-page: 920 year: 1985 end-page: 925 ident: BIB53 publication-title: Journal of Antibiotics contributor: fullname: Kanbe – volume: 95 start-page: 1173 year: 1980 end-page: 1179 ident: BIB60 publication-title: Biochemical and Biophysical Research Communications contributor: fullname: McLean – volume: vol. 3 start-page: 1314 year: 1974 end-page: 1319 ident: BIB43 publication-title: Methods of Enzymatic Analysis contributor: fullname: Beutler – volume: 48 start-page: 198 year: 1999 end-page: 202 ident: BIB10 publication-title: Diabetes contributor: fullname: Szwergold – volume: 114 start-page: 1643 year: 2001 end-page: 1653 ident: BIB22 publication-title: Journal of Cell Science contributor: fullname: Dreyer – volume: 122 start-page: 271 year: 1997 end-page: 278 ident: BIB39 publication-title: Journal of Biochemistry contributor: fullname: Akanuma – volume: 43 start-page: 836 year: 1994 end-page: 841 ident: BIB1 publication-title: Diabetes contributor: fullname: Brownlee – volume: 212 start-page: 101 year: 1993 end-page: 105 ident: BIB11 publication-title: European Journal of Biochemistry contributor: fullname: Thornalley – volume: 1226 start-page: 145 year: 1994 end-page: 150 ident: BIB31 publication-title: Biochimica et Biophysica Acta contributor: fullname: Peterson – volume: 350 start-page: 121 year: 1991 end-page: 124 ident: BIB13 publication-title: Nature contributor: fullname: Knowles – volume: 48 start-page: 1865 year: 1994 end-page: 1870 ident: BIB71 publication-title: Biochemical Pharmacology contributor: fullname: Thornalley – volume: 54 start-page: 443 year: 1993 end-page: 449 ident: BIB33 publication-title: International Journal of Cancer contributor: fullname: Ray – start-page: 298 year: 1998 end-page: 303 ident: BIB51 publication-title: The Maillard Reaction in Foods and Medicine contributor: fullname: Szwergold – volume: 40 start-page: 1328 year: 1991 end-page: 1344 ident: BIB8 publication-title: Diabetes contributor: fullname: Jerums – volume: 1362 start-page: 232 year: 1997 end-page: 242 ident: BIB36 publication-title: Biochimica et Biophysica Acta contributor: fullname: Harding – volume: 251 start-page: 4565 year: 1976 end-page: 4569 ident: BIB55 publication-title: Journal of Biological Chemistry contributor: fullname: Norton – volume: 271 start-page: 19338 year: 1996 ident: 10.1016/S09254439(02)00219-3_BIB50 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.271.32.19338 contributor: fullname: Nagaraj – volume: 954 start-page: 309 issue: 3 year: 1988 ident: 10.1016/S09254439(02)00219-3_BIB26 publication-title: Biochimica et Biophysica Acta doi: 10.1016/0167-4838(88)90086-6 contributor: fullname: Ryzlak – volume: 280 start-page: C867 year: 2001 ident: 10.1016/S09254439(02)00219-3_BIB65 publication-title: American Journal of Physiology. Cell Physiology doi: 10.1152/ajpcell.2001.280.4.C867 contributor: fullname: Dumaswala – volume: 20 start-page: 397 year: 1996 ident: 10.1016/S09254439(02)00219-3_BIB4 publication-title: Leukemia Research doi: 10.1016/0145-2126(95)00162-X contributor: fullname: Kang – volume: 277 start-page: 2554 year: 2002 ident: 10.1016/S09254439(02)00219-3_BIB68 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M100385200 contributor: fullname: Godbout – volume: 7 start-page: 65 year: 1989 ident: 10.1016/S09254439(02)00219-3_BIB32 publication-title: Cell Biochemistry and Function doi: 10.1002/cbf.290070111 contributor: fullname: Leoncini – volume: 1362 start-page: 232 year: 1997 ident: 10.1016/S09254439(02)00219-3_BIB36 publication-title: Biochimica et Biophysica Acta doi: 10.1016/S0925-4439(97)00084-7 contributor: fullname: Hook – volume: 263 start-page: 15335 year: 1988 ident: 10.1016/S09254439(02)00219-3_BIB25 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)37593-3 contributor: fullname: Ercolani – volume: 404 start-page: 787 year: 2000 ident: 10.1016/S09254439(02)00219-3_BIB64 publication-title: Nature doi: 10.1038/35008121 contributor: fullname: Nishikawa – volume: 118 start-page: 146 year: 1991 ident: 10.1016/S09254439(02)00219-3_BIB16 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Tilton – volume: 182 start-page: 91 year: 1994 ident: 10.1016/S09254439(02)00219-3_BIB19 publication-title: Neuroscience Letters doi: 10.1016/0304-3940(94)90214-3 contributor: fullname: Seipp – volume: 89 Pt D start-page: 326 year: 1982 ident: 10.1016/S09254439(02)00219-3_BIB42 publication-title: Methods in Enzymology doi: 10.1016/S0076-6879(82)89059-9 contributor: fullname: Byers – volume: 58 start-page: 641 year: 1999 ident: 10.1016/S09254439(02)00219-3_BIB67 publication-title: Biochemical Pharmacology doi: 10.1016/S0006-2952(99)00132-X contributor: fullname: Abordo – volume: 41 start-page: 1442 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB59 publication-title: Diabetologia doi: 10.1007/s001250051090 contributor: fullname: Obrosova – volume: 928 start-page: 48 year: 2001 ident: 10.1016/S09254439(02)00219-3_BIB5 publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.2001.tb05634.x contributor: fullname: Yim – volume: 42 start-page: 801 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB38 publication-title: Diabetes doi: 10.2337/diab.42.6.801 contributor: fullname: Williamson – volume: 263 start-page: 1665 year: 1988 ident: 10.1016/S09254439(02)00219-3_BIB37 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)77928-9 contributor: fullname: Hyslop – volume: 95 start-page: 1173 year: 1980 ident: 10.1016/S09254439(02)00219-3_BIB60 publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/0006-291X(80)91596-X contributor: fullname: Gonzalez – volume: 267 start-page: 16771 year: 1992 ident: 10.1016/S09254439(02)00219-3_BIB30 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)41847-9 contributor: fullname: Dimmeler – volume: 212 start-page: 101 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB11 publication-title: European Journal of Biochemistry doi: 10.1111/j.1432-1033.1993.tb17638.x contributor: fullname: Phillips – volume: 802 start-page: 229 year: 1984 ident: 10.1016/S09254439(02)00219-3_BIB15 publication-title: Biochimica et Biophysica Acta doi: 10.1016/0304-4165(84)90166-1 contributor: fullname: Bird – volume: 47 start-page: A80 issue: Supplement 1 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB52 publication-title: Diabetes contributor: fullname: Beisswenger – volume: 14 start-page: 233 year: 1982 ident: 10.1016/S09254439(02)00219-3_BIB62 publication-title: Hormone and Metabolic Research doi: 10.1055/s-2007-1018980 contributor: fullname: Scionti – volume: 75 start-page: 225 year: 1983 ident: 10.1016/S09254439(02)00219-3_BIB47 publication-title: Journal of Membrane Biology doi: 10.1007/BF01871953 contributor: fullname: Freedman – volume: 1120 start-page: 113 year: 1992 ident: 10.1016/S09254439(02)00219-3_BIB49 publication-title: Biochimica et Biophysica Acta doi: 10.1016/0167-4838(92)90431-C contributor: fullname: Kato – volume: 329 start-page: 977 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB56 publication-title: New England Journal of Medicine doi: 10.1056/NEJM199309303291401 – volume: 309 start-page: 133 year: 1995 ident: 10.1016/S09254439(02)00219-3_BIB35 publication-title: Biochemical Journal doi: 10.1042/bj3090133 contributor: fullname: He – volume: 54 start-page: 443 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB33 publication-title: International Journal of Cancer doi: 10.1002/ijc.2910540315 contributor: fullname: Halder – volume: 251 start-page: 4565 year: 1976 ident: 10.1016/S09254439(02)00219-3_BIB55 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(17)33239-8 contributor: fullname: Hartman – volume: 38 start-page: 920 year: 1985 ident: 10.1016/S09254439(02)00219-3_BIB53 publication-title: Journal of Antibiotics doi: 10.7164/antibiotics.38.920 contributor: fullname: Endo – volume: 232 start-page: 1629 year: 1986 ident: 10.1016/S09254439(02)00219-3_BIB9 publication-title: Science doi: 10.1126/science.3487117 contributor: fullname: Brownlee – volume: 122 start-page: 271 year: 1997 ident: 10.1016/S09254439(02)00219-3_BIB39 publication-title: Journal of Biochemistry doi: 10.1093/oxfordjournals.jbchem.a021749 contributor: fullname: Aki – volume: 114 start-page: 1643 year: 2001 ident: 10.1016/S09254439(02)00219-3_BIB22 publication-title: Journal of Cell Science doi: 10.1242/jcs.114.9.1643 contributor: fullname: Dastoor – volume: 33 start-page: 1129 year: 2001 ident: 10.1016/S09254439(02)00219-3_BIB6 publication-title: International Journal of Biochemistry and Cell Biology doi: 10.1016/S1357-2725(01)00010-3 contributor: fullname: Amicarelli – volume: 414 start-page: 149 year: 1987 ident: 10.1016/S09254439(02)00219-3_BIB44 publication-title: Journal of Chromatography doi: 10.1016/0378-4347(87)80033-6 contributor: fullname: Ohmori – volume: 47 start-page: 657 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB72 publication-title: Metabolism, Clinical and Experimental doi: 10.1016/S0026-0495(98)90026-9 contributor: fullname: Leyva – volume: 273 start-page: 446 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB40 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.1.446 contributor: fullname: Shinohara – volume: vol. 3 start-page: 1314 year: 1974 ident: 10.1016/S09254439(02)00219-3_BIB43 contributor: fullname: Michal – volume: 50 start-page: 1959 year: 1986 ident: 10.1016/S09254439(02)00219-3_BIB14 publication-title: Agricultural and Biological Chemistry doi: 10.1271/bbb1961.50.1959 contributor: fullname: Hayashi – volume: 206 start-page: 17 year: 1992 ident: 10.1016/S09254439(02)00219-3_BIB45 publication-title: Analytical Biochemistry doi: 10.1016/S0003-2697(05)80005-3 contributor: fullname: McLellan – volume: 397 start-page: 414 year: 2002 ident: 10.1016/S09254439(02)00219-3_BIB23 publication-title: Archives of Biochemistry and Biophysics doi: 10.1006/abbi.2001.2691 contributor: fullname: Kim – volume: 5 start-page: 1311 year: 1996 ident: 10.1016/S09254439(02)00219-3_BIB21 publication-title: Human Molecular Genetics doi: 10.1093/hmg/5.9.1311 contributor: fullname: Koshy – volume: 275 start-page: H75 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB57 publication-title: American Journal of Physiology doi: 10.1152/ajpcell.1998.275.1.C75 contributor: fullname: Trueblood – volume: 40 start-page: 1328 year: 1991 ident: 10.1016/S09254439(02)00219-3_BIB8 publication-title: Diabetes doi: 10.2337/diab.40.10.1328 contributor: fullname: Soulis-Liparata – start-page: 298 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB51 contributor: fullname: Beisswenger – volume: 96 start-page: 85 year: 1980 ident: 10.1016/S09254439(02)00219-3_BIB61 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Tegos – volume: 248 start-page: 28 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB70 publication-title: Biochemical and Biophysical Research Communications doi: 10.1006/bbrc.1998.8806 contributor: fullname: Hipkiss – volume: 48 start-page: 1865 year: 1994 ident: 10.1016/S09254439(02)00219-3_BIB71 publication-title: Biochemical Pharmacology doi: 10.1016/0006-2952(94)90584-3 contributor: fullname: Lo – volume: 43 start-page: 836 year: 1994 ident: 10.1016/S09254439(02)00219-3_BIB1 publication-title: Diabetes doi: 10.2337/diab.43.6.836 contributor: fullname: Brownlee – volume: 66 start-page: 133 year: 1997 ident: 10.1016/S09254439(02)00219-3_BIB17 publication-title: Journal of Cellular Biochemistry doi: 10.1002/(SICI)1097-4644(19970801)66:2<133::AID-JCB1>3.0.CO;2-R contributor: fullname: Sirover – volume: 63 start-page: 801 year: 1998 ident: 10.1016/S09254439(02)00219-3_BIB7 publication-title: Life Sciences doi: 10.1016/S0024-3205(98)00336-1 contributor: fullname: Golej – volume: 21 start-page: 549 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB12 publication-title: Biochemical Society Transactions doi: 10.1042/bst0210549 contributor: fullname: Richard – volume: 2 year: 1996 ident: 10.1016/S09254439(02)00219-3_BIB20 publication-title: Nature Medicine doi: 10.1038/nm0396-347 contributor: fullname: Burke – volume: 91 start-page: 2470 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB63 publication-title: Journal of Clinical Investigation doi: 10.1172/JCI116482 contributor: fullname: McCance – volume: 177 start-page: 21 year: 1997 ident: 10.1016/S09254439(02)00219-3_BIB34 publication-title: Molecular and Cellular Biochemistry doi: 10.1023/A:1006831511527 contributor: fullname: Ray – volume: 48 start-page: 198 year: 1999 ident: 10.1016/S09254439(02)00219-3_BIB10 publication-title: Diabetes doi: 10.2337/diabetes.48.1.198 contributor: fullname: Beisswenger – volume: 1226 start-page: 145 year: 1994 ident: 10.1016/S09254439(02)00219-3_BIB31 publication-title: Biochimica et Biophysica Acta doi: 10.1016/0925-4439(94)90022-1 contributor: fullname: Novotny – volume: 50 start-page: 453 year: 1975 ident: 10.1016/S09254439(02)00219-3_BIB54 publication-title: European Journal of Biochemistry doi: 10.1111/j.1432-1033.1975.tb09823.x contributor: fullname: Milhausen – volume: 350 start-page: 121 year: 1991 ident: 10.1016/S09254439(02)00219-3_BIB13 publication-title: Nature doi: 10.1038/350121a0 contributor: fullname: Knowles – volume: 68 start-page: 2493 year: 1997 ident: 10.1016/S09254439(02)00219-3_BIB28 publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.1997.68062493.x contributor: fullname: Nakazawa – volume: 431 start-page: 239 year: 1988 ident: 10.1016/S09254439(02)00219-3_BIB46 publication-title: Journal of Chromatography doi: 10.1016/S0378-4347(00)83093-5 contributor: fullname: Ohmori – volume: 861 start-page: 151 year: 2000 ident: 10.1016/S09254439(02)00219-3_BIB3 publication-title: Brain Research doi: 10.1016/S0006-8993(00)02047-3 contributor: fullname: Shinpo – start-page: 882 year: 1963 ident: 10.1016/S09254439(02)00219-3_BIB41 publication-title: Journal of Laboratory and Clinical Medicine contributor: fullname: Beutler – volume: 76 start-page: 442 year: 2001 ident: 10.1016/S09254439(02)00219-3_BIB24 publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.2001.00033.x contributor: fullname: Mazzola – volume: 250 start-page: 625 year: 1988 ident: 10.1016/S09254439(02)00219-3_BIB66 publication-title: Biochemical Journal doi: 10.1042/bj2500625 contributor: fullname: Taylor – volume: 221 start-page: 1033 year: 1994 ident: 10.1016/S09254439(02)00219-3_BIB27 publication-title: European Journal of Biochemistry doi: 10.1111/j.1432-1033.1994.tb18821.x contributor: fullname: Schuppe-Koistinen – volume: 1432 start-page: 159 year: 1999 ident: 10.1016/S09254439(02)00219-3_BIB18 publication-title: Biochimica et Biophysica Acta doi: 10.1016/S0167-4838(99)00119-3 contributor: fullname: Sirover – volume: 27 start-page: 565 year: 1996 ident: 10.1016/S09254439(02)00219-3_BIB2 publication-title: General Pharmacology doi: 10.1016/0306-3623(95)02054-3 contributor: fullname: Thornalley – volume: 376 start-page: 17 year: 1999 ident: 10.1016/S09254439(02)00219-3_BIB69 publication-title: European Journal of Pharmacology doi: 10.1016/S0014-2999(99)00342-8 contributor: fullname: Tanaka – volume: 51 start-page: 1572 year: 2002 ident: 10.1016/S09254439(02)00219-3_BIB48 publication-title: Diabetes doi: 10.2337/diabetes.51.5.1580 contributor: fullname: Drummond – volume: 268 start-page: 6388 year: 1993 ident: 10.1016/S09254439(02)00219-3_BIB29 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)53264-6 contributor: fullname: Uchida – volume: 252 start-page: 2998 year: 1977 ident: 10.1016/S09254439(02)00219-3_BIB58 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(17)40462-5 contributor: fullname: Stevens |
SSID | ssj0000670 ssj0025309 |
Score | 2.0966613 |
Snippet | Methylglyoxal (MG) may be an important cause of diabetic complications. Its primary source is dihydroxyacetone phosphate (DHAP) whose levels are partially... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 98 |
SubjectTerms | Adult Carbohydrate metabolism Cells, Cultured Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Enzyme Inhibitors - therapeutic use Erythrocytes - drug effects Erythrocytes - metabolism Female Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenases - antagonists & inhibitors Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Hydrogen-Ion Concentration Male Methylglyoxal Middle Aged Oxidation-Reduction Pyruvaldehyde - blood Pyruvaldehyde - metabolism Red blood cell Sesquiterpenes - therapeutic use |
Title | Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes |
URI | https://dx.doi.org/10.1016/S09254439(02)00219-3 https://www.ncbi.nlm.nih.gov/pubmed/12527413 https://search.proquest.com/docview/72954232 |
Volume | 1637 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFH8aQwguCAaMAis-cICDaWLHSXzcqo1CYQdg0JvlODatVJJo7SRy4W_n2UnYdpiQOFmybOfpPef59-z3AfCqLLRP85RTU4qUJkILqq1JqGGpEzn-TybygcKfTtPZWfJhIRY7MB1iYbxbZa_7O50etHXfM-m5OWlWq8mXSPr0WmizBz8D6TN--tyePohvcXRVG4d7FhxM_eghfC5ECfcrvI7Ym7AG5TcdTzfBz3AMnTyA-z1-JIcdiQ9hx1Z7cKerKNnuwd3pUMDtETTv1q0JV0522ZaWctos602zRHRJQtd5jbsHTzHigxt8DQmiN0RXZPW3NO6W_KzLlUPaSO2Irzbdrn-s2_oXkrD27kYbHEyG-9vHcHZy_HU6o32BBWrQrNtSXcrUpcYipOAsLxPmmLFpKrl2OSt04mzm4lwbWaDhKIST3BVaZggyBZcmdvwJ7FZ1ZZ8CSUtu42DMMJnosigQCKJgpJYIOXSUjYAOfFVNl0dDXTqY9XJQEVNBDoqPIBuYr67tB4Wq_h8zXw6yUshw__6hK1tfbFTm3zQRQY5gvxPhJSVM-DQ-_Nl_f_U53AtuflGMeucF7G7PL-wBwpVtMYZbb3_HY7h9ePRt_tG37-ezU9_OP3-fj8Nu_QMPyOnW |
link.rule.ids | 315,786,790,3525,4521,24144,27602,27957,27958,45620,45698,45714,45909 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB1RqgouqNAPtqXgAwd6cDex4yQ-VqvSbQtcAImb5Th2d6UlidhFIpf-dsZOAvSAKvUaOc5oxhm_sWfmARyWhfZtnnJqSpHSRGhBtTUJNSx1Isf_yUS-UPj0LJ1eJj-vxNUaTIZaGJ9W2fv-zqcHb90_GffaHDfz-fg8kr69FsbsIc9A8hfw0sN5z9_w5U_81B2HgxYcTf3woX4ulAn3UxxF7HOYhPLn9qfn8GfYh45fw1YPIMnXTsZtWLPVDrzqKCXbHdiYDAxub6D5vmhNOHOys7a0lNNmVi-bGcJLEh7d1Lh8cBsjvrrBk0gQvSS6IvMHbtwVua7LuUPZSO2Ip5tuF78XbX2HIix8vtESB5PhAPctXB5_u5hMac-wQA3GdSuqS5m61FjEFJzlZcIcMzZNJdcuZ4VOnM1cnGsjC4wchXCSu0LLDFGm4NLEjr-D9aqu7C6QtOQ2DtEMk4kuiwKRIFpGaomYQ0fZCOigV9V0jTTUY4ZZbwcVMRXsoPgIskH56q8FodDX_-PNg8FWChXuL0B0Zevbpcr8pSZCyBG870z4KAkTvo8P__DfXz2AjenF6Yk6-XH26yNshpy_KEYntAfrq5tb-wmxy6rYD2vzHm3b5yU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glyceraldehyde-3-phosphate+dehydrogenase+activity+as+an+independent+modifier+of+methylglyoxal+levels+in+diabetes&rft.jtitle=Biochimica+et+biophysica+acta&rft.au=Beisswenger%2C+Paul+J&rft.au=Howell%2C+Scott+K&rft.au=Smith%2C+Kenneth&rft.au=Szwergold%2C+Benjamin+S&rft.date=2003-01-20&rft.issn=0006-3002&rft.volume=1637&rft.issue=1&rft.spage=98&rft_id=info:doi/10.1016%2FS09254439%2802%2900219-3&rft_id=info%3Apmid%2F12527413&rft.externalDocID=12527413 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0925-4439&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0925-4439&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0925-4439&client=summon |