RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus

• Published in: Nature microbiology Vol. 6; no. 2; pp. 209 - 220
• Main Authors: Pinel-Marie, Marie-Laure, Brielle, Régine, Riffaud, Camille, Germain-Amiot, Noëlla, Polacek, Norbert, Felden, Brice
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2021; Nature Publishing Group
• Subjects: 14/35; 14/63; 38/44; 38/77; 38/90; 631/326; 631/326/421; 631/337/384/521; 82/1; 82/29; 82/80; Antibiotics; Bacteria; Bacterial Proteins - biosynthesis; Bacterial Proteins - genetics; Biomedical and Life Sciences; Chronic infection; Drug Resistance, Bacterial; Infectious Diseases; Life Sciences; Medical Microbiology; Microbiology; Molecular modelling; mRNA; Nucleotide sequence; Parasitology; Pathogens; Polyribosomes; Polyribosomes - metabolism; Protein Biosynthesis; Protein synthesis; Ribosomes; RNA, Messenger - metabolism; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - metabolism; Staphylococcus aureus - pathogenicity; Toxicity; Toxin-Antitoxin Systems - physiology; Transfer RNA; Translation; Translation initiation; Translations; Virology

Persister cells are a subpopulation of transiently antibiotic-tolerant bacteria associated with chronic infection and antibiotic treatment failure. Toxin–antitoxin systems have been linked to persister cell formation but the molecular mechanisms leading to bacterial persistence are mostly unknown. H...