Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects

• Published in: Journal of clinical medicine Vol. 10; no. 4; p. 596
• Main Authors: Barosa, Cristina, Ribeiro, Rogério T., Andrade, Rita, Raposo, João F., Jones, John G.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.02.2021; MDPI
• Subjects: Analgesics; Biopsy; Clinical medicine; Corn syrup; Diabetes; Glucose; Insulin; Liver; Meals; Metabolism; Peptides; Plasma; Triglycerides; Urine; United States > US; Portugal; deuterated water; fructose; intestinal gluconeogenesis; glycemic profile; indirect pathway

Dietary fructose overshadows glucose in promoting metabolic complications. Intestinal fructose metabolism (IFM) protects against these effects in rodents, by favoring gluconeogenesis, but the extent of IFM in humans is not known. We therefore aimed to infer the extent of IFM by comparing the contrib...