Phenylboronic acid conjugated mPEG-b-PCL micelles as DOX carriers for enhanced drug encapsulation and controlled drug release

• Published in: European polymer journal Vol. 173; p. 111235
• Main Authors: Yin, Wang, Wang, Yixiu, Xiao, Yan, Mao, Anrong, Lang, Meidong
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.06.2022; Elsevier BV
• Subjects: Anti-tumor; Anticancer properties; Block copolymers; Catalytic polymerization; Conjugation; Control stability; Controlled release; Drug carriers; Drug delivery systems; Drug loading; Drugs; Encapsulation; Hydrogen; Hydrogen peroxide; Micelles; Organic chemicals; Particle size; Poly(ɛ-caprolactone); Polymeric micelles; Polymers; Ring opening polymerization; Self-assembly; Side effects; Anti-tumor; Drug loading; Poly(ɛ-caprolactone); Polymeric micelles; Controlled release

[Display omitted] •Block polymers with three pendant groups were prepared by ROP and post-modification.•PBA-modified DOX-loaded micelles have the highest drug loading efficiency.•PBA-modified DOX-loaded micelles can be selectively release DOX by triggering with H2O2.•PBA-modified DOX-loaded micelles...