Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 84; no. Pt B; pp. 424 - 439
• Main Authors: Luo, J., Norris, R.H., Gordon, S.L., Nithianantharajah, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 08.06.2018
• Subjects: Autism spectrum disorder; Behaviour; Epilepsy; Intellectual disability; Mouse models; Schizophrenia; SAPAP; SNAP25; GTP; SAP; Epilepsy; STXBP1; Schizophrenia; DLGAP; −; MAGUK; Intellectual disability; SV2A; Magi-1; PTZ; Y; Syb; Nlgn; NSF; PSD; PRRT2; Behaviour; Syt1; Syn; +; Syp; Sytx; Autism spectrum disorder; Dnm1; Mouse models; S-SCAM; SHANK; DLG; Nrxn

The genomic revolution has begun to unveil the enormous complexity and heterogeneity of the genetic basis of neurodevelopmental disorders such as such epilepsy, intellectual disability, autism spectrum disorder and schizophrenia. Increasingly, human mutations in synapse genes are being identified ac...